Evidence map›Paper›PMID 38150547›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2024

Hemopexin reverses activation of lung eIF2α and decreases mitochondrial injury in chlorine-exposed mice.

Sadis Matalon, Zhihong Yu, Shubham Dubey, Israr Ahmad, Emily M Stephens, Ammar Saadoon Alishlash, Ashley Meyers, Douglas Cossar, Donald Stewart, Edward P Acosta and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. A human airway-on-a-chip microphysiological system for modeling chlorine gas toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  2. Article
  3. The long road to Ithaca: a physiologist's journey.American journal of physiology. Cell physiology · 2025
    Review
  4. scFocus: Detecting branching probabilities in single-cell data with SAC.Computational and structural biotechnology journal · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Sadis MatalonDivision of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0003-0683-3700
Zhihong YuDivision of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Shubham DubeyDivision of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Israr AhmadDivision of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-6164-9247
Emily M StephensDivision of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0003-0142-3075
Ammar Saadoon AlishlashDivision of Pediatric Pulmonary and Sleep Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Ashley MeyersAntoXa Corporation, Toronto, Ontario, Canada.
Douglas CossarAntoXa Corporation, Toronto, Ontario, Canada.
Donald StewartAntoXa Corporation, Toronto, Ontario, Canada.
Edward P AcostaDivision of Clinical Pharmacology, Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Kyoko KojimaO'Neal Comprehensive Cancer Center, Mass Spectrometry and Proteomics Shared Facility, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Tamas JillingDivision of Neonatology, Department of Pediatrics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.ORCID 0000-0002-6200-3851
James A MobleyDivision of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
University of Alabama at Birmingham · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
PATHOPHYSIOLOGY OF SUBLETHAL OXYGEN IN INJURED LUNGSR01HL031197 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MARK N GILLESPIE, Sadis Matalon · 1985 to 2026
$4.2M
Sickle Cell Trait Mice are More Susceptible to Chlorine Exposure and Haptoglobin Improves the OutcomesR21ES034226 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALISHLASH, AMMAR · 2022 to 2024
$594k
Mitigation of Chlorine Injury to MitochondriaR21ES032956 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MATALON, SADIS · 2021 to 2022
$422k
Esomeprazole counteracts chlorine toxicity in pregnant animalsR21ES031559 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JILLING, TAMAS SANDOR · 2021 to 2022
$408k
Division of Cancer Prevention, National Cancer Institute (DCP, NCI) 3P30CA013148HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) 1R21ES034226;HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) 5R2 ES031559HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) R21 ES032956-01HHS | NIH | NHLBI | NHLBI Division of Intramural Research (DIR) 2R01HL031197-28NCI NIH HHS P30 CA013148NHLBI NIH HHS R01 HL031197NIEHS NIH HHS R21 ES031559NIEHS NIH HHS R21 ES032956NIEHS NIH HHS R21 ES034226
6 · The paper itself

Abstract

We assessed the mechanisms by which nonencapsulated heme, released in the plasma of mice after exposure to chlorine (Cl

Indexed as

Acute Lung InjuryChlorineAnimalsDNA, MitochondrialHemeHemopexinLungMiceMice, Inbred C57BLMitochondriaProteomeProteomicsChlorineDNA, MitochondrialHemeHemopexinProteomelung injurymitochondrial DNAproteomicsrecombinant hemopexin

Identifiers

PMID38150547
PMCPMC11281818
OpenAlexW4390263587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.