Evidence map›Paper›PMID 38150155›Full record

SynthesisClinical oral investigations2023

Is withdrawal of antiresorptive agents necessary before and after tooth extraction? A systematic review.

Daisuke Takeda, Hiroshi Kurita, Yoshihisa Kashima, Takumi Hasegawa, Masaaki Miyakoshi, Shin-Ichi Yamada, Yoshiko Yamamura, Sakiko Soutome

Abstract readSystematic ReviewCase Reports
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Daisuke TakedaDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Hiroshi KuritaDepartment of Dentistry and Oral Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan. hkurita@shinshu-u.ac.jp.
Yoshihisa KashimaDepartment of Oral and Maxillofacial Surgery, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
Takumi HasegawaDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Masaaki MiyakoshiDepartment of Maxillofacial Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Shin-Ichi YamadaDepartment of Oral and Maxillofacial Surgery, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Yoshiko YamamuraDepartment of Oral Surgery, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Sakiko SoutomeDepartment of Oral Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Kobe University · JPKagoshima University · JPNagasaki University · JPShinshu University · JPTokushima University · JPTokyo Medical and Dental University · JPUniversity of Toyama · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe need for prevention and management of medication-related osteonecrosis of the jaw (MRONJ) has increased with the growing number of patients using antiresorptive agents. The scope of this systematic review (SR) was to determine whether the withdrawal of antiresorptive agents is necessary for tooth extractions in patients receiving each of the antiresorptive medications. MATERIALS AND

methodsThe searches were performed using the MEDLINE databases. We selected SRs, randomized controlled trials (RCTs), prospective and retrospective non-randomized clinical (observational) studies, and case reports/case series in this order of preference.

resultsWe included one SR, one RCT, five observational studies, and three case reports. Meta-analyses were not conducted because the RCT had an extremely small sample size and the observational studies had different definitions of intervention and comparison that could not be integrated across studies. In this SR, no studies showed a benefit (i.e., a reduction in the incidence of osteonecrosis of the jaw) of short-term withdrawal of antiresorptive agents for tooth extraction. Additionally, no studies examined the harm (i.e., an increase in femoral and vertebral fractures and skeletal-related events during bone metastasis) of withdrawal for tooth extraction.

conclusionsWe were unable to determine whether withdrawal before and after tooth extraction is necessary with a high certainty of evidence. Future systematic reviews including RCTs with larger samples are expected to provide such evidence. CLINICAL RELEVANCE: This systematic review provides evidence-based information for multidisciplinary collaborations related to patients receiving antiresorptive agents.

Indexed as

Bone Density Conservation AgentsOsteonecrosisDental CareFemurHumansTooth ExtractionBone Density Conservation AgentsAntiresorptive agentsMedication-related osteonecrosis of the jawSystematic reviewTooth extractionWithdrawal

Identifiers

PMID38150155
OpenAlexW4390273813

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.