Evidence map›Paper›PMID 38150133›Full record

SynthesisBrain imaging and behavior2024

Grey matter structural alterations in anxiety disorders: a voxel-based meta-analysis.

Han Liu, Zeqi Hao, Shasha Qiu, Qianqian Wang, Linlin Zhan, Lina Huang, Youbin Shao, Qing Wang, Chang Su, Yikang Cao and 7 more

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Brain imaging and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Han Liu *School of Psychology, Zhejiang Normal University, Jinhua, China.
Zeqi Hao *School of Psychology, Zhejiang Normal University, Jinhua, China.
Shasha Qiu *School of Psychology, Zhejiang Normal University, Jinhua, China.
Qianqian WangSchool of Psychology, Zhejiang Normal University, Jinhua, China.
Linlin ZhanSchool of Western Languages, Heilongjiang University, Heilongjiang, China.
Lina HuangDepartment of Radiology, Changshu No.2 People's Hospital, The Affiliated Changshu Hospital of Xuzhou Medical University, Changshu, Jiangsu, China.
Youbin ShaoSchool of Psychology, Zhejiang Normal University, Jinhua, China.
Qing WangResearch Center of Brain and Cognitive Neuroscience, Liaoning Normal University, Dalian, China.
Chang SuSchool of Psychology, Zhejiang Normal University, Jinhua, China.
Yikang CaoSchool of Information and Electronics Technology, Jiamusi University, Jiamusi, China.
Jiawei SunSchool of Information and Electronics Technology, Jiamusi University, Jiamusi, China.
Chunjie WangInstitute of Brain Science, Department of Psychology, School of Education, Hangzhou Normal University, Hangzhou, China.
Yating LvCenter for Cognition and Brain Disorders, the Affiliated Hospital, Hangzhou Normal University, Hangzhou, China.
Mengting LiSchool of Psychology, Zhejiang Normal University, Jinhua, China.
Wenbin ShenDepartment of Radiology, Changshu No.2 People's Hospital, The Affiliated Changshu Hospital of Xuzhou Medical University, Changshu, Jiangsu, China.
Huayun LiSchool of Psychology, Zhejiang Normal University, Jinhua, China. lihuayun99@163.com.
Xize JiaSchool of Psychology, Zhejiang Normal University, Jinhua, China. jiaxize@foxmail.com.

Funding

Changshu Second People's Hospital Science and Technology Project CSEY2021055National Natural Science Foundation of China 82001898Open Research Fund of College of Teacher Education, Zhejiang Normal University jykf20003Open Research Fund of the Psychology Department of Zhejiang Normal University in 2022 Open Research Fund of the Psychology Department of Zhejiang Normal University in 2022
6 · The paper itself

Abstract

Anxiety disorders (ADs) are a group of prevalent and destructive mental illnesses, but the current understanding of their underlying neuropathology is still unclear. Employing voxel-based morphometry (VBM), previous studies have demonstrated several common brain regions showing grey matter volume (GMV) abnormalities. However, contradictory results have been reported among these studies. Considering that different subtypes of ADs exhibit common core symptoms despite different diagnostic criteria, and previous meta-analyses have found common core GMV-altered brain regions in ADs, the present research aimed to combine the results of individual studies to identify common GMV abnormalities in ADs. Therefore, we first performed a systematic search in PubMed, Embase, and Web of Science on studies investigating GMV differences between patients with ADs and healthy controls (HCs). Then, the anisotropic effect-size signed differential mapping (AES-SDM) was applied in this meta-analysis. A total of 24 studies (including 25 data sets) were included in the current study, and 906 patients with ADs and 1003 HCs were included. Compared with the HCs, the patients with ADs showed increased GMV in the left superior parietal gyrus, right angular gyrus, left precentral gyrus, and right lingual gyrus, and decreased GMV in the bilateral insula, bilateral thalamus, left caudate, and right putamen. In conclusion, the current study has identified some abnormal GMV brain regions that are related to the pathological mechanisms of anxiety disorders. These findings could contribute to a better understanding of the underlying neuropathology of ADs.

Indexed as

Anxiety DisordersBrainGray MatterMagnetic Resonance ImagingHumansOrgan SizeAnxiety disordersGrey matter volumeMeta-analysisVoxel-based morphometry

Identifiers

PMID38150133

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.