ReviewFrontiers in endocrinology2023
Endogenous and microbial biomarkers for periodontitis and type 2 diabetes mellitus.
Review in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Exosomal microRNAs in Periodontitis: From Molecular Footprints to Clinical Frontiers.ACS pharmacology & translational science · 2026Review
- Article
- Comparison of salivary caspase-3 biomarker in peri-implantitis among type 2 diabetic patients.Bioinformation · 2026Article
- From biological evidence to clinical application: a scoping review of oral fluid biomarkers in type 2 diabetic periodontitis.Frontiers in oral health · 2026Review
- The oral microbiome in aging: a window into health and longevity.Journal of oral microbiology · 2025Review
- The Prevalence of the Periodontal PathogenClinical, cosmetic and investigational dentistry · 2025Article
- Periodontal therapy mitigates inflammation via TNF-α reduction and improves glycolipid metabolism in diabetic patients: a cross-sectional cohort study.Frontiers in endocrinology · 2025Article
- The Involvement of Resolvins in Pathological Mechanisms of Periodontal Disease Associated with Type 2 Diabetes: A Narrative Review.International journal of molecular sciences · 2024Review
- MiR-146a Is Mutually Regulated by High Glucose-Induced Oxidative Stress in Human Periodontal Ligament Cells.International journal of molecular sciences · 2024Article
- Apelin - A New Kid on the Block in Periodontology.Oral health & preventive dentistry · 2024Review
- Higher Prevalence of the Periodontal PathogenPathogens (Basel, Switzerland) · 2024Article
- Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population.Journal of oral microbiology · 2024Article
- Diagnostic accuracy of salivary hemoglobin, lactate dehydrogenase and Interleukin-6 to determine chronic periodontitis and tooth loss in type 2 diabetics.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been well documented that there is a two-way relationship between diabetes mellitus and periodontitis. Diabetes mellitus represents an established risk factor for chronic periodontitis. Conversely, chronic periodontitis adversely modulates serum glucose levels in diabetic patients. Activated immune and inflammatory responses are noted during diabetes and periodontitis, under the modulation of similar biological mediators. These activated responses result in increased activity of certain immune-inflammatory mediators including adipokines and microRNAs in diabetic patients with periodontal disease. Notably, certain microbes in the oral cavity were identified to be involved in the occurrence of diabetes and periodontitis. In other words, these immune-inflammatory mediators and microbes may potentially serve as biomarkers for risk assessment and therapy selection in diabetes and periodontitis. In this review, we briefly provide an updated overview on different potential biomarkers, providing novel diagnostic and therapeutic insights on periodontal complications and diabetes mellitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.