Evidence map›Paper›PMID 38149013›Full record

ArticleFrontiers in cellular and infection microbiology2023

Development and validation of a rabbit model of

Emmanuelle Gras, Trang T T Vu, Nhu T Q Nguyen, Vuvi G Tran, Yanjie Mao, Nguyen D Tran, Nam H Mai, Oliver X Dong, David H Jung, Natalia L P P Iorio and 12 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Bridging bench and bedside: translational omics ofEuropean respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  2. Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Animal models ofFrontiers in microbiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 9 countries.

Emmanuelle Gras *Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.
Trang T T Vu *Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.
Nhu T Q NguyenDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.
Vuvi G TranDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.
Yanjie MaoDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.
Nguyen D TranDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.
Nam H MaiDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.
Oliver X DongDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.
David H JungDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.
Natalia L P P IorioDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.
Helvecio C C PovoaDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.
Marcos Gabriel PinheiroDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.
Fabio Aguiar-AlvesDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.
William J WeissPre-Clinical Services at UNT Health Science Center, Fort Worth, TX, United States.
Bo ZhengClinical Pharmacology & DMPK, AstraZeneca, Gaithersburg, MD, United States.
Lily I ChengEarly Vaccines and Immune Therapies, AstraZeneca, Gaithersburg, MD, United States.
Charles K StoverEarly Vaccines and Immune Therapies, AstraZeneca, Gaithersburg, MD, United States.
Bret R SellmanEarly Vaccines and Immune Therapies, AstraZeneca, Gaithersburg, MD, United States.
Antonio DiGiandomenicoEarly Vaccines and Immune Therapies, AstraZeneca, Gaithersburg, MD, United States.
Laure GibaultPathology Department, George Pompidou European Hospital, Paris, France.
Florent ValourDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.
Binh An DiepDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, United States.
University of California, San Francisco · USAstraZeneca (United States) · USUniversidade Federal Fluminense · BRÉcole Normale Supérieure de Lyon · FRHôpital Européen Georges-Pompidou · FRUniversity of Medicine and Pharmacy at Ho Chi Minh City · VNUniversity of North Texas Health Science Center · US

Funding

FDA HHS
6 · The paper itself

Abstract

Background: New drugs targeting antimicrobial resistant pathogens, including Methods: We report here an FDA-funded study to develop a rabbit model of non-ventilated pneumonia with Results: In a rabbit model of non-ventilated pneumonia, endobronchial challenge with live Conclusion: The rabbit model may be used to help predict clinical efficacy of new antibacterial drugs for the treatment of non-ventilated

Indexed as

PneumoniaPseudomonas InfectionsAnimalsAnti-Bacterial AgentsDrug DevelopmentHumansMeropenemMicrobial Sensitivity TestsPseudomonas aeruginosaRabbitsTobramycinAnti-Bacterial AgentsMeropenemTobramycinmeropenemnon-ventilated pneumonia modelpreclinical efficacy model validationPseudomonas aeruginosarabbit modeltobramycin

Identifiers

PMID38149013
PMCPMC10750358
OpenAlexW4389565562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.