ArticleFrontiers in medicine2023
Efficacy of canakinumab in patients with Still's disease across different lines of biologic therapy: real-life data from the International AIDA Network Registry for Still's Disease.
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Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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8citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- The Asia-Pacific League of Associations for Rheumatology Consensus Recommendations on the Management of Systemic Juvenile Idiopathic Arthritis (Juvenile Still's Disease).International journal of rheumatic diseases · 2026Guideline
- Macrophage Activation Syndrome Associated with Adult-onset Still's Disease Successfully Treated with Plasma Exchange and Canakinumab.Internal medicine (Tokyo, Japan) · 2026Article
- Effects of first-line biologic immunomodulation compared with non-biologic therapies in adult-onset Still's disease: a two-center cohort study.Arthritis research & therapy · 2026Article
- Interleukin-1 receptor antagonist autoantibodies in Still's disease: Mechanistic insights and laboratory testing.World journal of methodology · 2026Review
- Pharmacologic management of renal involvement in monogenic autoinflammatory diseases.European journal of medical research · 2026Review
- Association between canakinumab dose and long-term remission in Still's disease: insights from the AIDA network registry.Frontiers in pharmacology · 2026Article
- Advancing multidisciplinary management of pediatric hyperinflammatory disorders.Frontiers in pediatrics · 2025Review
- Cardiovascular involvement in children with COVID-19 temporally related multisystem inflammatory syndrome (MIS-C): can cardiac magnetic resonance arrive to the heart of the problem?Italian journal of pediatrics · 2024Article
Corrections and comments
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Authors and funding
59 authors at 20 institutions in 8 countries.
Antonio VitaleDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
Valeria CaggianoDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
Petros P SfikakisJoint Academic Rheumatology Program, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Lorenzo DagnaDivision of Immunology, Transplants and Infectious Diseases, Università Vita-Salute San Raffaele, Milan, Italy.
Giuseppe LopalcoDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) Policlinic Hospital, University of Bari, Bari, Italy.
Gaafar RagabRheumatology and Clinical Immunology Unit, Internal Medicine Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Francesco La TorreDepartment of Pediatrics, Pediatric Rheumatology Center, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy.
Ibrahim A AlmaghlouthRheumatology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Maria Cristina MaggioUniversity Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) "G. D'Alessandro", University of Palermo, Palermo, Italy.
Jurgen SotaDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
Abdurrahman TufanDepartment of Internal Medicine, Division of Rheumatology, Gazi University Hospital, Ankara, Türkiye.
Andrea Hinojosa-AzaolaDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Florenzo IannoneDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) Policlinic Hospital, University of Bari, Bari, Italy.
Roberta LoconteDepartment of Pediatrics, Pediatric Rheumatology Center, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy.
Katerina LaskariJoint Academic Rheumatology Program, The First Department of Propaedeutic and Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Haner DireskeneliDepartment of Internal Medicine, Division of Rheumatology, Marmara University, Faculty of Medicine, Istanbul, Türkiye.
Piero RuscittiRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Maria MorroneDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) Policlinic Hospital, University of Bari, Bari, Italy.
Henrique A Mayrink GiardiniRheumatology Division, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil.
Alexandros PanagiotopoulosJoint Academic Rheumatology Program, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Ilenia Di ColaRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Eduardo Martín-NaresDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Sara MontiDivision of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Ludovico De StefanoDivision of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Rıza Can KardasDepartment of Internal Medicine, Division of Rheumatology, Gazi University Hospital, Ankara, Türkiye.
Rahime DuranDepartment of Internal Medicine, Division of Rheumatology, Gazi University Hospital, Ankara, Türkiye.
Corrado CampochiaroDivision of Immunology, Transplants and Infectious Diseases, Università Vita-Salute San Raffaele, Milan, Italy.
Alessandro TomelleriDivision of Immunology, Transplants and Infectious Diseases, Università Vita-Salute San Raffaele, Milan, Italy.
Abdulaziz Mohammed AlabdulkareemRheumatology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Carla GaggianoDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
Maria Tarsia, Department of Molecular Medicine and DevelopmentClinical Pediatrics, University of Siena, Siena, Italy.
Elena BartoloniRheumatology Unit, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Mery RomeoPediatric Nephrology and Rheumatology Unit, Azienda Ospedaliera Universitaria (AOU), "G. Martino", Messina, Italy.
Mohamed A HusseinRheumatology and Clinical Immunology Unit, Internal Medicine Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Ahmed Hatem LaymounaRheumatology and Clinical Immunology Unit, Internal Medicine Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Isabele Parente de Brito AntonelliRheumatology Division, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil.
Marilia Ambiel DagostinRheumatology Division, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil.
Lampros FotisDepartment of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens, Zografou, Greece.
Sara BindoliRheumatology Unit, Department of Medicine, University of Padua, Padua, Italy.
Luca NavariniClinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Rome, Italy.
Fatma Alibaz-OnerDepartment of Internal Medicine, Division of Rheumatology, Marmara University, Faculty of Medicine, Istanbul, Türkiye.
Gizem SevikDepartment of Internal Medicine, Division of Rheumatology, Marmara University, Faculty of Medicine, Istanbul, Türkiye.
Micol FrassiSpedali Civili and Department of Clinical and Experimental Sciences, Rheumatology and Clinical Immunology, University of Brescia, European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center, Brescia, Italy.
Francesco CicciaDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Daniela IaconoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Francesca CrisafulliSpedali Civili and Department of Clinical and Experimental Sciences, Rheumatology and Clinical Immunology, University of Brescia, European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center, Brescia, Italy.
Piero PortincasaClinica Medica "A. Murri", Division of Internal Medicine, Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari Aldo Moro, Bari, Italy.
Nour JaberClinica Medica "A. Murri", Division of Internal Medicine, Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari Aldo Moro, Bari, Italy.
Perla Ayumi Kawakami-CamposDepartment of Ophthalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Ewa Wiesik-SzewczykDepartment of Internal Medicine, Pneumonology, Allergology and Clinical Immunology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Medicine, National Research Institute, Warsaw, Poland.
Annamaria IagnoccoAcademic Rheumatology Centre, Dipartimento Scienze Cliniche e Biologiche, Università degli Studi di Torino, Torino, Italy.
Gabriele SimoniniNEUROFARBA Department, Rheumatology Unit, Meyer Children's Hospital IRCCS, University of Florence, Florence, Italy.
Paolo SfrisoRheumatology Unit, Department of Medicine, University of Padua, Padua, Italy.
Alberto BalistreriBioengineering and Biomedical Data Science Lab, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Roberto GiacomelliClinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Rome, Italy.
Giovanni ContiPediatric Nephrology and Rheumatology Unit, Azienda Ospedaliera Universitaria (AOU), "G. Martino", Messina, Italy.
Bruno FredianiDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
Claudia FabianiOphthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Luca CantariniDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
University of Siena · ITUniversity of Bari Aldo Moro · ITNational and Kapodistrian University of Athens · GRCairo University · EGGazi University · TRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXMarmara University · TRVita-Salute San Raffaele University · ITAzienda Ospedaliera Universitaria Policlinico "G. Martino" · ITKing Saud University · SAOspedale Pediatrico Giovanni XXIII · ITUniversità Campus Bio-Medico · ITUniversity of Brescia · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of L'Aquila · ITUniversity of Padua · ITUniversity of Pavia · ITCentral Clinical Hospital · PLMeyer Children's Hospital · IT
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The effectiveness of canakinumab may change according to the different times it is used after Still's disease onset. This study aimed to investigate whether canakinumab (CAN) shows differences in short- and long-term therapeutic outcomes, according to its use as different lines of biologic treatment. Methods: Patients included in this study were retrospectively enrolled from the AutoInflammatory Disease Alliance (AIDA) International Registry dedicated to Still's disease. Seventy-seven (51 females and 26 males) patients with Still's disease were included in the present study. In total, 39 (50.6%) patients underwent CAN as a first-line biologic agent, and the remaining 38 (49.4%) patients were treated with CAN as a second-line biologic agent or subsequent biologic agent. Results: No statistically significant differences were found between patients treated with CAN as a first-line biologic agent and those previously treated with other biologic agents in terms of the frequency of complete response ( Conclusion: Canakinumab has proved to be effective in patients with Still's disease, regardless of its line of biologic treatment.
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AOSDAutoInflammatory diseasespersonalized medicinerare diseasestreatment
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