ReviewFrontiers in allergy2023
Population-based incidence of all-cause anaphylaxis and its development over time: a systematic review and meta-analysis.
Review in Frontiers in allergy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Quality of life and psychological wellbeing of adults with anaphylaxis: a mixed method systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Pooled it
- Adrenaline, Takotsubo Cardiomyopathy, Anaphylaxis, and Kounis Syndrome (ATAK) Complex: Clinical Phenotypes, Differential Diagnosis, and Management.JACC. Case reports · 2026Article
- Novelties in the pragmatic management of anaphylaxis in pediatric age.European journal of pediatrics · 2026Review
- Adherence to the Australian acute anaphylaxis clinical care standard and outcomes in a regional Queensland specialist outpatient service.Internal medicine journal · 2026Article
- Overview of allergic disease: Anaphylaxis - WAO White Book on Allergy 2026 - 2.11.The World Allergy Organization journal · 2026Review
- Acute Allergic Reactions and Severe Anaphylaxis: Underlying Causes, Management Strategies, and Future Directions.Archives of internal medicine research · 2026Article
- Nationwide epinephrine auto-injector dispensing in Greece: a drug-utilization study providing insights into anaphylaxis epidemiology and emergency-treatment preparedness.Frontiers in allergy · 2026Article
- Nutritional Status Is Not a Predictor of Anaphylaxis Severity in a Pediatric Cohort: A Retrospective Analysis.Nutrients · 2025Article
- FDA approves neffy nasal spray for treatment of anaphylaxis in adult and pediatric patients.Annals of medicine and surgery (2012) · 2025Article
- Article
- Integrated Metabolomic and Gut Microbiome Profiles Reveal Postmortem Biomarkers of Fatal Anaphylaxis.International journal of molecular sciences · 2025Article
- Article
- Seizures as an Initial Manifestation of Severe Anaphylaxis Following Intrathecal Contrast Injection: A Case Report.Case reports in critical care · 2025Article
- Incidence and trends of anaphylaxis among inpatients from 2003 to 2023 in Wuhan, China: A multicenter retrospective study.The World Allergy Organization journal · 2024Article
- Blood Transcriptomics Identifies Multiple Gene Expression Pathways Associated with the Clinical Efficacy ofInternational journal of molecular sciences · 2024Article
- Grand challenges in genetics and epidemiology of allergic diseases: from genome to exposome and back.Frontiers in allergy · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: It is extremely difficult to compare studies investigating the frequency of anaphylaxis making it challenging to satisfactorily assess the worldwide incidence rate. Using a systematic review and meta-analysis, this publication aims to determine the current incidence of all-cause anaphylaxis worldwide. Additionally, we investigated whether the incidence of anaphylaxis has changed over time and which factors influence the rates determined by individual studies. Methods: A literature search was performed in four databases. All articles that reported relevant information on population-based incidence rates of all-cause anaphylaxis were included. The protocol was published on INPLASY, the International Platform of Registered Systematic Review and Meta-analysis Protocols. Results: The database query and screening process resulted in 46 eligible articles on anaphylaxis. The current incidence worldwide was found to be approximately 46 cases per 100,000 population per year (95% CI 21-103). Evaluating confounding factors showed that studies using allergy clinics and hospitalizations as data source result in comparably low rates. Moreover, children are less prone to develop anaphylaxis compared to the general population. Using a random effects Poisson model we calculated a yearly increase of anaphylaxis incidence by 7.4% (95% CI 7.3-7.6, Discussion: This seems to be the first approach to analyze every reported all-cause anaphylaxis incidence rate until 2017 for an at most accurate determination of its epidemiology. Based on these results, future research could investigate the underlying causes for the rising incidence in order find ways to decrease the condition's frequency. Systematic Review Registration: inplasy.com, identifier [INPLASY202330047].
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.