Evidence map›Paper›PMID 38148892›Full record

ArticleLeukemia research reports2024

A rare association of a high grade glioblastoma, cerebral abscess and acute lymphoblastic leukemia in a child with Noonan syndrome.

Wiem Boufrikha, Rim Rakez, Inaam Bizid, M Maher Hadhri, Manel Njima, Sarra Boukhris, M Adnene Laatiri

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia research reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 68% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Noonan Syndrome, Cancer Risk, and Growth Hormone TreatmentJournal of clinical research in pediatric endocrinology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wiem BoufrikhaDepartment of Hematology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Rim RakezDepartment of Hematology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Inaam BizidDepartment of Hematology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
M Maher HadhriDepartment of Neurosurgery, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Manel NjimaDepartment of Histopathology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Sarra BoukhrisDepartment of Hematology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
M Adnene LaatiriDepartment of Hematology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Hospital Fatuma Bourguiba Monastir · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noonan syndrome is a genetic disorder frequently caused by PTPN11 mutations. Patients with Noonan syndrome are characterized by facial dysmorphism, short stature and congenital heart defects and they have a reported predisposition to malignancies such as leukemia, and solid and central nervous system tumors. Here, we report a case of a 14-year-old boy with Noonan syndrome treated for T-cell acute lymphoblastic leukemia who presented with 2 concomitant abnormalities: cerebral abscess and high grade glioblastoma. This exceptional association exhibits to a poorer prognosis and may sometimes delay the diagnosis and therefore the therapeutic intervention.

Indexed as

Acute lymphoblastic leukemiaBrain tumorCase reportCerebral abscessGenetic diseases

Identifiers

PMID38148892
PMCPMC10750179
OpenAlexW4389219539

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.