Evidence map›Paper›PMID 38148489›Full record

ArticleThe neuroradiology journal2024

Association of brain arterial diameters with demographic and anatomical factors in a multi-national pooled analysis of cohort studies.

Victor J Del Brutto, Farid Khasiyev, Minghua Liu, Antonio Spagnolo-Allende, Ye Qiao, Jesus D Melgarejo Arias, Vanessa A Guzman, Kay C Igwe, Danurys L Sanchez, Howard Andrews and 20 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The neuroradiology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Assessing changes on large cerebral arteries in CADASIL: Preliminary insights from a case-control analysis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2025
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 13 institutions in 5 countries.

Victor J Del BruttoUniversity of Miami, Miami, FL, USA.
Farid KhasiyevSt. Louis University, St. Louis, MO, USA.ORCID 0000-0002-3127-0973
Minghua LiuColumbia University, New York, NY, USA.
Antonio Spagnolo-AllendeColumbia University, New York, NY, USA.
Ye QiaoJohns Hopkins University, Baltimore, MD, USA.
Jesus D Melgarejo AriasLaboratory of Neuroscience, University of Zulia, Maracaibo, Venezuela.
Vanessa A GuzmanColumbia University, New York, NY, USA.
Kay C IgweColumbia University, New York, NY, USA.
Danurys L SanchezColumbia University, New York, NY, USA.
Howard AndrewsNew York State Psychiatric Institute, New York, NY, USA.
Clarissa D MoralesColumbia University, New York, NY, USA.
Meagan T FarrellHarvard University, Harvard Center for Population and Development Studies, Cambridge, MA, USA.
Darina T BassilHarvard University, Harvard Center for Population and Development Studies, Cambridge, MA, USA.
Sudha SeshadriUniversity of Texas San Antonio, San Antonio, TX, USA.
Ryan G WagnerMRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), University of the Witwatersrand, Johannesburg, South Africa.
Victor MngomezuluDepartment of Diagnostic Radiology, University of the Witwatersrand, Johannesburg, South Africa.
Jennifer ManlyColumbia University, New York, NY, USA.
Mitchell Sv ElkindColumbia University, New York, NY, USA.
Lisa BerkmanHarvard University, Harvard Center for Population and Development Studies, Cambridge, MA, USA.
Jose R RomeroBoston University, Boston, MA, USA.
Gladys E MaestreLaboratory of Neuroscience, University of Zulia, Maracaibo, Venezuela.
Oscar H Del BruttoUniversidad Espiritu Santo, Samborondon, Ecuador.ORCID 0000-0003-1917-8805
Adam M BrickmanColumbia University, New York, NY, USA.
Narayanaswamy VenketasubramanianRaffles Neuroscience Centre, Raffles Hospital, Singapore.
Christopher ChenDepartment of Pharmacology, National University of Singapore, Singapore.
Caroline RobertDepartment of Pharmacology, National University of Singapore, Singapore.
Saima HilalDepartment of Pharmacology, National University of Singapore, Singapore.
Tatjana RundekUniversity of Miami, Miami, FL, USA.
Bruce A WassermanJohns Hopkins University, Baltimore, MD, USA.
Jose GutierrezColumbia University, New York, NY, USA.
Columbia University · USHarvard University Press · USNational University of Singapore · SGUniversidad del Zulia · VEUniversity of Miami · USUniversity of the Witwatersrand · ZAJohns Hopkins University · USNew York Psychoanalytic Society and Institute · USRaffles Institution · SGSaint Louis University · USThe University of Texas at San Antonio · USUniversidad de Especialidades Espíritu Santo · ECUniversity of Maryland, Baltimore · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SCOTT A SMALL · 2020 to 2026
$30.1M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONR01NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 1993 to 2019
$19.2M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7M
Epidemiological and Genetic Investigations of Blood-Based Biomarkers for Alzheimer's Disease in the Multiethnic, Washington Heights, Inwood, Columbia Aging Project (WHICAP)R01AG072474 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, MANLY, JENNIFER JAIE · 2021 to 2025
$13.3M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Epidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1M
Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9M
Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF SpectrumR01HL131029 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Gregory Dyer Lewis, Matthew G. Nayor · 2016 to 2026
$7.7M
NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL105930NHLBI NIH HHS R01 HL131029NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIA NIH HHS P30 AG066462NIA NIH HHS R01 AG036469NIA NIH HHS R01 AG037212NIA NIH HHS R01 AG047645NIA NIH HHS R01 AG054066NIA NIH HHS R01 AG054491NIA NIH HHS R01 AG057709NIA NIH HHS R01 AG066162NIA NIH HHS R01 AG072474NIA NIH HHS R03 AG054186NIA NIH HHS RF1 AG054023NIA NIH HHS U01 AG052409NINDS NIH HHS R01 NS029993NINDS NIH HHS R01 NS036286
6 · The paper itself

Abstract

background and purposeBrain arterial diameters are markers of cerebrovascular disease. Demographic and anatomical factors may influence arterial diameters. We hypothesize that age, sex, height, total cranial volume (TCV), and persistent fetal posterior cerebral artery (fPCA) correlate with brain arterial diameters across populations.

methodsParticipants had a time-of-flight MRA from nine international cohorts. Arterial diameters of the cavernous internal carotid arteries (ICA), middle cerebral arteries (MCA), and basilar artery (BA) were measured using LAVA software. Regression models assessed the association between exposures and brain arterial diameters.

resultsWe included 6,518 participants (mean age: 70 ± 9 years; 41% men). Unilateral fPCA was present in 13.2% and bilateral in 3.2%. Larger ICA, MCA, and BA diameters correlated with older age (Weighted average [WA] per 10 years: 0.18 mm, 0.11 mm, and 0.12 mm), male sex (WA: 0.24 mm, 0.13 mm, and 0.21 mm), and TCV (WA: for one TCV standard deviation: 0.24 mm, 0.29 mm, and 0.18 mm). Unilateral and bilateral fPCAs showed a positive correlation with ICA diameters (WA: 0.39 mm and 0.73 mm) and negative correlation with BA diameters (WA: -0.88 mm and -1.73 mm). Regression models including age, sex, TCV, and fPCA explained on average 15%, 13%, and 25% of the ICA, MCA, and BA diameter interindividual variation, respectively. Using height instead of TCV as a surrogate of head size decreased the R-squared by 3% on average.

conclusionBrain arterial diameters correlated with age, sex, TCV, and fPCA. These factors should be considered when defining abnormal diameter cutoffs across populations.

Indexed as

Magnetic Resonance AngiographyAgedAged, 80 and overAge FactorsBasilar ArteryBrainCarotid Artery, InternalCerebral ArteriesCohort StudiesFemaleHumansMaleMiddle AgedMiddle Cerebral ArteryPosterior Cerebral ArterySex FactorsArterial diametersbasilar arterycarotid arterycohort studiesfetal posterior cerebral arterymiddle cerebral artery

Identifiers

PMID38148489
PMCPMC11138338
OpenAlexW4390270444

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.