Evidence map›Paper›PMID 38148465›Full record

ArticleMedical oncology (Northwood, London, England)2023

The emerging role of breast cancer derived extracellular vesicles-mediated intercellular communication in ovarian cancer progression and metastasis.

Melis Rahime Yıldırım, Oğuz Kaan Kırbaş, Hüseyin Abdik, Fikrettin Şahin, Ezgi Avşar Abdik

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 67% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Melis Rahime YıldırımDepartment of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, 34755, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-7539-1750
Oğuz Kaan KırbaşDepartment of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, 34755, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-7510-474X
Hüseyin AbdikDepartment of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, İstanbul Sabahattin Zaim University, 34303, Istanbul, Turkey.ORCID http://orcid.org/0000-0003-3756-0645
Fikrettin ŞahinDepartment of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, 34755, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-7208-8967
Ezgi Avşar AbdikDepartment of Genomics, Faculty of Aquatic Sciences, Istanbul University, 34134, Istanbul, Turkey. e.avsarabdik@istanbul.edu.tr.ORCID http://orcid.org/0000-0003-0132-3234
Yeditepe University · TRİstanbul Sabahattin Zaim Üniversitesi · TRIstanbul University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is one of the most occurring cancer types in women worldwide and metastasizes to several organs such as bone, lungs, liver, brain, and ovaries. Extracellular vesicles (EVs) mediate intercellular signaling which has a profound effect on tumor development and metastasis. Recent developments in the field of EVs provide an opportunity to investigate the roles of EVs released from tumor cells in metastasis. In this study, we compared the effects of metastatic breast cancer-derived EVs on both nonluteinized granulosa HGrC1 and ovarian cancer OVCAR-3 cells in terms of proliferation, invasion, apoptosis, and gene expression levels. EVs were isolated from the culture medium of metastatic breast cancer cell line MDA-MB-231 by ultracentrifugation. Cell proliferation, apoptosis, cell cycle, invasion, and cellular uptake analysis were performed to clarify the roles of tumor-derived EVs in both cells. 6.85 × 10

Indexed as

Breast NeoplasmsExtracellular VesiclesOvarian NeoplasmsApoptosisCell CommunicationCell Line, TumorFemaleHumansBreast cancerExtracellular vesiclesFatty acid profileInvasionMetastasisOvarian cancer

Identifiers

PMID38148465
OpenAlexW4390225534

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.