Evidence map›Paper›PMID 38147818›Full record

ArticleCancer research and treatment2024

Invasiveness of Upper Tract Urothelial Carcinoma: Clinical Significance and Integrative Diagnostic Strategy.

Bokyung Ahn, Doeun Kim, Kye Jin Park, Ja-Min Park, Sun Young Yoon, Bumsik Hong, Yong Mee Cho, Deokhoon Kim

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Article in Cancer research and treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Bokyung AhnDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Doeun KimDepartment of Medical Science, Biomedical Science, University of Ulsan College of Medicine, Seoul, Korea.
Kye Jin ParkDepartment of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Ja-Min ParkDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Sun Young YoonDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Bumsik HongDepartment of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Yong Mee ChoDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Deokhoon KimDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Funding

Asan Institute for Life Sciences, Asan Medical Center 2022IL0014-1Ministry of Science, ICT and Future Planning 2019R1A2C1088246
6 · The paper itself

Abstract

purposeIn this study, we aimed to determine the clinicopathologic, radiologic, and molecular significance of the tumor invasiveness to further stratify the patients with high-grade (HG) upper tract urothelial carcinoma (UTUC) who can be treated less aggressively. MATERIALS AND

methodsClinicopathologic and radiologic characteristics of 166 surgically resected HG UTUC (48 noninvasive, and 118 invasive) cases were evaluated. Six noninvasive UTUC cases with intratumoral tumor grade heterogeneity were selected for whole-exome sequencing (WES) to understand the underlying molecular pathophysiology. Barcode-tagging sequencing was done for validation of the target genes from WES data.

resultsPatients with noninvasive UTUC showed no cancer-specific death with better cancer-specific survival (p < 0.001) and recurrence-free survival (p < 0.001) compared to the patients with invasive UTUC. Compared to the invasive UTUC, noninvasive UTUC was correlated to a low grade (LG) on the preoperative abdominal computed tomography (CT) grading system (p < 0.001), histologic intratumoral tumor grade heterogeneity (p=0.018), discrepancy in preoperative urine cytology diagnosis (p=0.018), and absence of urothelial carcinoma in situ (p < 0.001). WES of the heterogeneous components showed mutually shared HRAS and FGFR3 mutations shared between the HG and LG components. HRAS mutation was associated with the lower grade on preoperative abdominal CT and intratumoral tumor grade heterogeneity (p=0.045 and p < 0.001, respectively), whereas FGFR3 mutation was correlated to the absence of carcinoma in situ (p < 0.001).

conclusionAccording to our comprehensive analysis, HG noninvasive UTUC can be preoperatively suspected based on distinct preoperative radiologic, cytologic, histologic, and molecular features. Noninvasive HG UTUC shows excellent prognosis and thus should be treated less aggressively.

Indexed as

Neoplasm InvasivenessAgedAged, 80 and overBiomarkers, TumorCarcinoma, Transitional CellClinical RelevanceExome SequencingFemaleHumansMaleMiddle AgedMutationNeoplasm GradingPrognosisReceptor, Fibroblast Growth Factor, Type 3Urologic NeoplasmsBiomarkers, TumorReceptor, Fibroblast Growth Factor, Type 3Barcode-tagged sequencingInvasive urothelial carcinomaNoninvasive urothelial carcinomaUpper tract urothelial carcinomaWhole-exome sequencing

Identifiers

PMID38147818
PMCPMC11261206

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.