Evidence map›Paper›PMID 38147550›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation.

Hongling Hu, Sheng Luo, Pinglin Lai, Mingqiang Lai, Linlin Mao, Sheng Zhang, Yuanjun Jiang, Jiaxin Wen, Wu Zhou, Xiaolin Liu and 11 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  7. Modulation of senescent LeprStem cell research & therapy · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 2 countries.

Hongling Hu *Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China.
Sheng Luo *Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.ORCID 0009-0004-6397-0845
Pinglin Lai *Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China.
Mingqiang Lai *Department of Orthopaedics, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong 510900, China.
Linlin MaoDepartment of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.
Sheng ZhangDepartment of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.
Yuanjun JiangDepartment of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.
Jiaxin WenDepartment of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.
Wu ZhouDepartment of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.
Xiaolin LiuDepartment of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.
Liang WangGuangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China.
Minjun HuangGuangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China.ORCID 0000-0003-1307-9283
Yanjun HuDepartment of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Xiaoyang ZhaoDepartment of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.ORCID 0000-0003-2544-8293
Laixin XiaDepartment of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.
Weijie ZhouDepartment of Pathology, Nanfang Hospital, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.ORCID 0000-0002-0021-9454
Yu JiangDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.
Zhipeng ZouDepartment of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.ORCID 0000-0003-0421-4738
Anling LiuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.
Bin GuoDepartment of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.
Xiaochun BaiGuangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China.ORCID 0000-0001-9631-4781
Southern Medical University · CNThird Affiliated Hospital of Southern Medical University · CNNanfang Hospital · CNUniversity of Pittsburgh · US

Funding

China Postdoctoral Science Foundation (China Postdoctoral Foundation Project) 2022M711510GDSTC | Basic and Applied Basic Research Foundation of Guangdong Province () 2019A1515110148MOST | National Natural Science Foundation of China (NSFC) 81991511MOST | National Natural Science Foundation of China (NSFC) 82301002MOST | National Natural Science Foundation of China (NSFC) 92268204
6 · The paper itself

Abstract

Leptin protein was thought to be unique to leptin receptor (LepR), but the phenotypes of mice with mutation in LepR [

Indexed as

LeptinOssification, HeterotopicAngiopoietin-Like Protein 4AnimalsLigandsMiceMice, Inbred C57BLOsteogenesisReceptors, LeptinAngiopoietin-Like Protein 4Angptl4 protein, mouseLeptinleptin receptor, mouseLigandsReceptors, LeptinANGPTL4heterotopic ossificationleptin receptor

Identifiers

PMID38147550
PMCPMC10769826
OpenAlexW4390237554

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.