Evidence map›Paper›PMID 38147125›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2024

IL-4-secreting CD40L

Muziying Liu, Ziqiang Yang, Qielan Wu, Yunru Yang, Dan Zhao, Qingyu Cheng, Yajuan Li, Gengyuan Liu, Changfeng Zhao, Jun Pan and 3 more

Abstract read
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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Muziying Liu *Anhui Institute of Pediatric Research, Anhui Provincial Children's Hospital, Hefei, 230051, China.
Ziqiang Yang *Anhui Institute of Pediatric Research, Anhui Provincial Children's Hospital, Hefei, 230051, China.
Qielan Wu *Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, 230071, China.
Yunru YangInstitute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, 230071, China.
Dan ZhaoInstitute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, 230071, China.
Qingyu ChengSchool of Basic Medical Sciences, University of Science and Technology of China, Hefei, 230027, China.
Yajuan LiDepartment of Clinical Laboratory, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Gengyuan LiuCAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, University of Science and Technology of China, Hefei, 230026, China.
Changfeng ZhaoSchool of Basic Medical Sciences, University of Science and Technology of China, Hefei, 230027, China.
Jun PanSchool of Basic Medical Sciences, University of Science and Technology of China, Hefei, 230027, China.
Yuwei ZhangSchool of Basic Medical Sciences, University of Science and Technology of China, Hefei, 230027, China.
Fang DengAnhui Institute of Pediatric Research, Anhui Provincial Children's Hospital, Hefei, 230051, China. dengfang@ahmu.edu.cn.
Tengchuan JinInstitute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, 230071, China. jint@ustc.edu.cn.
University of Science and Technology of China · CNAnhui Provincial Children's Hospital · CNAnhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHere, we explored the phenotype and function of MAIT cells in the peripheral blood of patients with HSP.

methodsBlood samples from HSP patients and HDs were assessed by flow cytometry and single-cell RNA sequencing to analyze the proportion, phenotype, and function of MAIT cells. Th-cytokines in the serum of HSP patients were analyzed by CBA. IgA in cocultured supernatant was detected by CBA to analyze antibody production by B cells.

resultsThe percentage of MAIT cells in HSP patients was significantly reduced compared with that in HDs. Genes related to T cell activation and effector were up-regulated in HSP MAIT cells, indicating a more activated phenotype. In addition, HSP MAIT cells displayed a Th2-like profile with the capacity to produce more IL-4 and IL-5, and IL-4 was correlated with IgA levels in the serum of HSP patients. Furthermore, CD40L was up-regulated in HSP MAIT cells, and CD40L

conclusionOur data demonstrate that MAIT cells in HSP patients exhibit an activated phenotype. The enhanced IL-4 production and CD40L expression of MAIT cells in HSP patients could take part in the pathogenesis of HSP.

Indexed as

IgA VasculitisMucosal-Associated Invariant T CellsAntibody FormationCD40 LigandHumansImmunoglobulin AInterleukin-4CD40 LigandIL4 protein, humanImmunoglobulin AInterleukin-4CD40LHeonch–Schönlein purpuraIgAIL-4MAIT

Identifiers

PMID38147125
OpenAlexW4390231401

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.