Evidence map›Paper›PMID 38147124›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2024

Severity of critical illness correlates with CD3-low expression on iNKT-cells among septic surgical patients.

Daithi S Heffernan, Chun-Shiang Chung, Alfred Ayala

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Daithi S HeffernanDivision of Surgical Research, Department of Surgery, Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, Rhode Island, 02903, USA. dheffernan@brown.edu.
Chun-Shiang ChungDivision of Surgical Research, Department of Surgery, Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, Rhode Island, 02903, USA.
Alfred AyalaDivision of Surgical Research, Department of Surgery, Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, Rhode Island, 02903, USA.
Brown University · USRhode Island Hospital · US

Funding

Mechanisms of Immune Dysfunction and Morbid Outcome in Response to Shock/SepsisR35GM118097 · NIGMS · RHODE ISLAND HOSPITAL · PI AYALA, ALFRED · 2016 to 2025
$6.3M
Sepsis Induced Changes in iNKT-Cells and their Effect on Phagocyte FunctionK08GM110495 · NIGMS · RHODE ISLAND HOSPITAL · PI HEFFERNAN, DAVID · 2015 to 2018
$786k
NIGMS NIH HHS K08 GM110495NIGMS NIH HHS R35 GM118097NIH HHS K08-GM110495NIH HHS R35 GM118097
6 · The paper itself

Abstract

backgroundiNKT-cells are innate regulatory lymphocytes capable of directing immune and inflammatory responses to sepsis. Repeat stimulation of iNKT-cells leads to the induction of anergy with the emergence of a hyporesponsive CD3

methodsiNKT-cells were isolated from critical ill surgical patients with sepsis and phenotyped for CD3 expression. This was correlated with degree of severity of illness, as denoted by APACHE-II score.

resultsComparing healthy volunteers to critically ill septic patients, it was noted that increasing severity of sepsis was associated with increasing frequency of circulating CD3

conclusionThe emergence of CD3

Indexed as

Critical IllnessSepsisHumansLymphocytesAPACHE IICD3iNKT-cellsSepsisSurgery

Identifiers

PMID38147124
PMCPMC11963472
OpenAlexW4390233989

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.