Evidence map›Paper›PMID 38147074›Full record

SynthesisEuropean journal of clinical pharmacology2024

Proton pump inhibitors associated with an increased risk of mortality in elderly: a systematic review and meta-analysis.

Hyun Jin Song, Hyun-Ju Seo, Xinyi Jiang, Nakyung Jeon, Yoon Jae Lee, In-Hyuk Ha

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of clinical pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Hyun Jin Song *School of Pharmacy, Sungkyunkwan University, Suwon, South Korea. hyunjin.song@ufl.edu.
Hyun-Ju Seo *College of Nursing, Chungnam National University, Daejeon, South Korea.
Xinyi JiangCollege of Pharmacy, University of Florida, Gainesville, FL, USA.
Nakyung JeonCollege of Pharmacy, Pusan National University, Busan, South Korea.
Yoon Jae LeeJaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, South Korea.
In-Hyuk HaJaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, South Korea.
Jaseng Medical Foundation · KRChungnam National University · KRPusan National University · KRSungkyunkwan University · KRUniversity of Florida · US

Funding

Sungkyunkwan University 2017
6 · The paper itself

Abstract

purposeThe increased use of proton pump inhibitors (PPIs) in the elderly has raised concerns about potential severe adverse effects. Our systematic review investigated the mortality associated with PPI use in elderly populations.

methodsWe searched MEDLINE, EMBASE, and the Cochrane Library for relevant publications until August 2022. We included randomized controlled trials (RCTs), quasi-RCTs, and observational studies on the association between proton pump inhibitors and mortality in the elderly. To estimate the pooled relative risk (RR) and 95% confidence interval (CI), the inverse-variance random effect model was used. Heterogeneity was assessed using the I

resultsA total of 4 RCTs and 36 cohort studies were included in the meta-analysis. Four RCTs showed that there was no significant association between PPIs and the risk of death. From 23 observational studies (26 cohorts), the use of proton pump inhibitors was not significantly associated with increased mortality in the elderly (RR 1.14; 95% CI, 0.90-1.45). However, when controlling for covariates from 33 observational studies (41 cohorts), proton pump inhibitors in older adults aged 50 years or more were significantly associated with a 15% higher risk of mortality compared to nonusers (RR 1.15; 95% CI, 1.10-1.20).

conclusionsOur meta-analysis of RCTs found that PPIs did not show a significant association with increased mortality risk in older adults. However, the meta-analysis of cohort studies and long-term follow-up studies showed a higher increased risk of death with PPI use in older adults. The prescription of PPIs in patients aged 50 years or older should be carefully considered.

Indexed as

Proton Pump InhibitorsAgedAge FactorsHumansMiddle AgedMortalityObservational Studies as TopicRandomized Controlled Trials as TopicProton Pump InhibitorsElderlyMeta-analysisMortalityProton pump inhibitorsSystematic review

Identifiers

PMID38147074
OpenAlexW4390231261

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.