Evidence map›Paper›PMID 38147050›Full record

ArticlePsychological review2024

Deep rest: An integrative model of how contemplative practices combat stress and enhance the body's restorative capacity.

Alexandra D Crosswell, Stefanie E Mayer, Lauren N Whitehurst, Martin Picard, Sheyda Zebarjadian, Elissa S Epel

Abstract read
In one paragraph

Article in Psychological review, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
  2. Energy constraint on human health.Trends in endocrinology and metabolism: TEM · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. The energy resistance principle.Cell metabolism · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexandra D CrosswellDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco.ORCID 0000-0002-1632-2931
Stefanie E MayerDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco.ORCID 0000-0001-7041-4434
Lauren N WhitehurstDepartment of Psychology, University of Kentucky.ORCID 0000-0002-0123-8614
Martin PicardDepartment of Psychiatry, Division of Behavioral Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center.ORCID 0000-0003-2835-0478
Sheyda ZebarjadianDepartment of Counseling Psychology, University of Denver.
Elissa S EpelDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco.ORCID 0000-0002-8004-2571

Funding

University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI GREGORY A JICHA · 2021 to 2026
$23.5M
Stress, diet quality, and biological aging across the lifespanR24AG048024 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EPEL, ELISSA S., MENDES, WENDY BERRY · 2014 to 2025
$6.2M
Psychology & Medicine: Translational Research on Stress, Behavior and DiseaseT32MH019391 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ADLER, NANCY E, EPEL, ELISSA S. · 1991 to 2022
$4.4M
Advancing Psychosocial & Biobehavioral Approaches to Improve Emotional Well-BeingU24AG072699 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EPEL, ELISSA S., MENDES, WENDY BERRY · 2021 to 2024
$2.8M
Understanding and Reversing the Effects of Early Life Adversity on Midlife Health: Improving Daily Psychological Stress Responses using an Ecological Momentary InterventionR00AG062778 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAYER, STEFANIE EVA · 2021 to 2023
$747k
Stress resilience and aging in Alzheimers disease and dementia caregiversK01AG057859 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CROSSWELL, ALEXANDRA DUPONT · 2018 to 2022
$652k
NIA NIH HHS K01 AG057859NIA NIH HHS P30 AG072946NIA NIH HHS R00 AG062778NIA NIH HHS R24 AG048024NIA NIH HHS U24 AG072699NIMH NIH HHS T32 MH019391
6 · The paper itself

Abstract

Engaging in contemplative practice like meditation, yoga, and prayer, is beneficial for psychological and physical well-being. Recent research has identified several underlying psychological and biological pathways that explain these benefits. However, there is not yet consensus on the underlying overlapping physiological mechanisms of contemplative practice benefits. In this article, we integrate divergent scientific literatures on contemplative practice interventions, stress science, and mitochondrial biology, presenting a unified biopsychosocial model of how contemplative practices reduce stress and promote physical health. We argue that engaging in contemplative practice facilitates a restorative state termed "deep rest," largely through safety signaling, during which energetic resources are directed toward cellular optimization and away from energy-demanding stress states. Our model thus presents a framework for how contemplative practices enhance positive psychological and physiological functioning by optimizing cellular energy consumption. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Indexed as

MeditationYogaHumans

Identifiers

PMID38147050
PMCPMC11003855

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.