Evidence map›Paper›PMID 38147031›Full record

Trial reportJournal of the International AIDS Society2023

"I felt special!": a qualitative study of peer-delivered HIV self-tests, STI self-sampling kits and PrEP for transgender women in Uganda.

Andrew Mujugira, Beyonce Karungi, Jackson Mugisha, Agnes Nakyanzi, Monica Bagaya, Brenda Kamusiime, Alisaati Nalumansi, Grace Kakoola Nalukwago, Vicent Kasiita, Chris Collins Twesigye and 7 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the International AIDS Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04328025 (Peer-Delivered HIV Self-Testing, STI Self-Sampling and PrEP for Transgender Women in Uganda), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04328025 naunknown statusnot on this map

Peer-Delivered HIV Self-Testing, STI Self-Sampling and PrEP for Transgender Women in Uganda

TypeinterventionalSponsorMakerere UniversityRan2020 to 2022Enrolled82ConditionsHIV, Sexually Transmitted Infections, PrEP, Transgender WomenArmsPeer-delivered HIV self-testing, STI self-sampling and PrEP
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Andrew MujugiraThe Infectious Diseases Institute Limited, Makerere University, Kampala, Uganda.ORCID 0000-0001-6646-6733
Beyonce KarungiTransgender Equality Uganda, Kampala, Uganda.
Jackson MugishaThe Infectious Diseases Institute Limited, Makerere University, Kampala, Uganda.
Agnes NakyanziThe Infectious Diseases Institute Limited, Makerere University, Kampala, Uganda.
Monica BagayaThe Infectious Diseases Institute Limited, Makerere University, Kampala, Uganda.
Brenda KamusiimeThe Infectious Diseases Institute Limited, Makerere University, Kampala, Uganda.
Alisaati NalumansiThe Infectious Diseases Institute Limited, Makerere University, Kampala, Uganda.
Grace Kakoola NalukwagoThe Infectious Diseases Institute Limited, Makerere University, Kampala, Uganda.
Vicent KasiitaThe Infectious Diseases Institute Limited, Makerere University, Kampala, Uganda.
Chris Collins TwesigyeThe Infectious Diseases Institute Limited, Makerere University, Kampala, Uganda.
Olivia NampewoThe Infectious Diseases Institute Limited, Makerere University, Kampala, Uganda.
Rogers NsubugaThe Infectious Diseases Institute Limited, Makerere University, Kampala, Uganda.
Kikulwe Robert NyanziThe Infectious Diseases Institute Limited, Makerere University, Kampala, Uganda.
Timothy MuwongeThe Infectious Diseases Institute Limited, Makerere University, Kampala, Uganda.
Monique A WyattDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Norma C WareDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-5039-9991
Jessica E HabererCenter for Global Health, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-5845-3190
Infectious Diseases Institute · UGHarvard University · USBrigham and Women's Hospital · USUniversity of Washington · US

Funding

Optimizing mHealth for adherence monitoring and interventionK24MH114732 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI HABERER, JESSICA ELIZABETH · 2017 to 2021
$800k
Transgender Men and HIV in Uganda: PrEP Uptake and PersistenceR34MH121084 · NIMH · INFECTIOUS DISEASES INSTITUTE · PI MUJUGIRA, ANDREW · 2019 to 2021
$584k
NIMH NIH HHS K24 MH114732NIMH NIH HHS K24MH114732NIMH NIH HHS R34 MH121084NIMH NIH HHS R34MH121084
6 · The paper itself

Abstract

introductionPeer delivery is a client-centred approach that could maximize the coverage and impact of HIV services for transgender women (TGW). We conducted qualitative interviews to examine how peer-delivered HIV self-testing (HIVST), sexually transmitted infection self-sampling (STISS) and oral pre-exposure prophylaxis (PrEP) influenced prevention choices among TGW and their intimate partners in Uganda.

methodsWithin a cluster randomized trial of peer-delivered HIVST, STISS and PrEP among HIV-negative TGW (NCT04328025), we conducted 55 qualitative interviews with 30 TGW, 15 intimate partners and 10 TGW peers (August 2021-February 2022). TGW interviews explored: (1) HIV self-test and PrEP experiences; (2) HIVST with intimate partners; and (3) descriptions of self-sampling for STI testing. Partner interviews covered: (1) experiences with HIVST; (2) disclosure of HIV status to intimate partner; and (3) descriptions of sexual behaviours after testing. Peer interview topics included: (1) intervention delivery experiences; and (2) recommendations for peer-delivered HIV prevention services to TGW, including psychological support and coping strategies. Qualitative data were analysed using an inductive content analytic approach.

resultsPeer-delivered combination prevention was valued by this group of TGW and their partners. (1) Peer services extended beyond delivering HIV/STI kits and PrEP refills to caring for individual health and wellbeing by providing stigma coping strategies. Peer psychosocial support empowered research participants to become "HIVST ambassadors," teach non-study TGW about self-testing and PrEP, and encourage linkage to care. (2) HIVST with intimate partners and mutual disclosure of HIV status strengthened partnered relationships. PrEP use after both partners tested HIV negative implied infidelity. (3) Self-sampling enabled TGW to take control of their STI testing and avoid the embarrassment of exposing their bodies. Privacy and confidentiality motivated the uptake of STI testing and treatment.

conclusionsIn this sample of TGW from Uganda, peer delivery of HIVST, STISS and PrEP refills benefitted individual prevention efforts and extended to a new linkage of TGW not engaged in care. Integrating peer services into differentiated PrEP delivery could increase HIV/STI test coverage and PrEP use in this vulnerable population.

Indexed as

HIV InfectionsSexually Transmitted DiseasesTransgender PersonsFemaleHumansMaleSexual BehaviorUgandaAfricaHIV self-testingpeer deliverypre-exposure prophylaxisself-samplingsexually transmitted infections

Identifiers

PMID38147031
PMCPMC10750840
OpenAlexW4390227206

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.