Evidence map›Paper›PMID 38146625›Full record

ArticleJournal of medicinal chemistry2024

Development of Highly Potent, G-Protein Pathway Biased, Selective, and Orally Bioavailable GPR84 Agonists.

Pinqi Wang, Arun Raja, Vincent B Luscombe, Carole J R Bataille, Daniel Lucy, Vanessa V Rogga, David R Greaves, Angela J Russell

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Pinqi WangDepartment of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.
Arun RajaDepartment of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.
Vincent B LuscombeSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K.ORCID 0000-0002-2886-4017
Carole J R BatailleDepartment of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.
Daniel LucyDepartment of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.
Vanessa V RoggaDepartment of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.
David R GreavesSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K.
Angela J RussellDepartment of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.ORCID 0000-0003-3610-9369
Mansfield University · USUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Orphan G-protein-coupled receptor 84 (GPR84) is a receptor that has been linked to cancer, inflammatory, and fibrotic diseases. We have reported DL-175 as a biased agonist at GPR84 which showed differential signaling via G

Indexed as

GTP-Binding ProteinsReceptors, G-Protein-Coupledbeta-ArrestinsSignal TransductionStructure-Activity Relationshipbeta-ArrestinsGTP-Binding ProteinsReceptors, G-Protein-Coupled

Identifiers

PMID38146625
PMCPMC10788923
OpenAlexW4390236657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.