Evidence map›Paper›PMID 38146377›Full record

ArticleGerms2023

The emergence of multidrug-resistant Gram-positive bloodstream infections in India - a single center prospective cohort study.

Nakka Vihari, Gopal Krishana Bohra, Ram Ratan Yadev, Deepak Kumar, Durga Shankar Meena, Vibhor Tak, Ankur Sharma, Vijaylaxmi Nag, Mahendra Kumar Garg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Germs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. An Overview ofIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nakka VihariMD, Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, India.
Gopal Krishana BohraMD, Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, 342005, India.
Ram Ratan YadevMS, Department of General Surgery, S.K. Medical College, Sikar, India.
Deepak KumarMD, Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, India.
Durga Shankar MeenaMD, Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, India.
Vibhor TakMD, Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, India.
Ankur SharmaMD, Department of Anesthesiology and Critical Care, All India Institute of Medical Sciences, Jodhpur, India.
Vijaylaxmi NagMD, Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, India.
Mahendra Kumar GargDM, Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, India.
All India Institute of Medical Sciences Jodhpur · INSarojini Naidu Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Gram-positive bloodstream infections (BSIs) are an emerging health concern, especially in resource-limited settings. There is a paucity of data regarding the antimicrobial resistance (AMR) pattern of Gram-positive BSIs. The rise in multidrug-resistant infections further convoluted antibiotic selection. We aimed to assess the incidence, clinical and microbiological profile, antimicrobial resistance (AMR) and outcome in Gram-positive BSIs. Methods: This was a single-center prospective study conducted at a tertiary care hospital in Western India. All patients (age ≥18 years) with culture-proven Gram-positive BSIs were included. Data were collected on all patients' demography, risk factors, AMR and clinical outcome. Results: A total of 210 clinically significant isolates were grown from July 2020 to December 2021. The incidence of Gram-positive BSIs was 29% (n=61); 55.9% of cases were healthcare-associated, while 44.1% were community-acquired. Coagulase-negative staphylococci (CoNS) were the major isolates (36.1%), followed by Conclusions: This study found substantial mortality with Gram-positive BSIs, especially MRSA infections. Moreover, the emergence of VRE and LRE is also alarming. Active surveillance of AMR and evaluation of mortality predictors may help overcome the therapeutic challenges in managing BSIs.

Indexed as

Bloodstream infectionsEnterococcusGram-positive bacteriaStaphylococcus aureusvancomycin

Identifiers

PMID38146377
PMCPMC10748842
OpenAlexW4389011309

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.