Evidence map›Paper›PMID 38146367›Full record

ArticleFrontiers in immunology2023

The

Myriam Rahmouni, Lorenzo De Marco, Jean-Louis Spadoni, Maxime Tison, Raissa Medina-Santos, Taoufik Labib, Josselin Noirel, Ryad Tamouza, Sophie Limou, Olivier Delaneau and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 3 countries.

Myriam RahmouniLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, Paris, France.
Lorenzo De MarcoLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, Paris, France.
Jean-Louis SpadoniLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, Paris, France.
Maxime TisonLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, Paris, France.
Raissa Medina-SantosLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, Paris, France.
Taoufik LabibLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, Paris, France.
Josselin NoirelLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, Paris, France.
Ryad TamouzaUniversité Paris Est Créteil, INSERM U955, IMRB, Laboratoire Neuro-Psychiatrie translationnelle, Créteil, France.
Sophie LimouNantes Université, Ecole Centrale Nantes, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI), Nantes, France.
Olivier DelaneauDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Jacques FellayGlobal Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Armand BensussanUnité INSERM U976, Hôpital Saint-Louis, Paris, France.
Sigrid Le ClercLaboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, Paris, France.
Paul J McLaren *Sexually Transmitted and Blood-Borne Infections Division at JC Wilt Infectious Diseases Research Centre, National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, MB, Canada.
Jean-François Zagury *Laboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, Paris, France.
Conservatoire National des Arts et Métiers · FRGénomique Bioinformatique et Applications · FRÉcole Polytechnique Fédérale de Lausanne · CHHôpital Saint-Louis · FRInserm · FRInstitut de Transplantation Urologie en Nephrologie · FRPublic Health Agency of Canada · CAUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: We have reanalyzed the genomic data of the International Collaboration for the Genomics of HIV (ICGH), centering on HIV-1 Elite Controllers. Methods: We performed a genome-wide Association Study comparing 543 HIV Elite Controllers with 3,272 uninfected controls of European descent. Using the latest database for imputation, we analyzed 35,552 Single Nucleotide Polymorphisms (SNPs) within the Major Histocompatibility Complex ( Results: Our analysis identified 2,626 SNPs significantly associated (p<5. 10-8) with elite control of HIV-1 infection, including well-established Discussion: These findings suggest that additional molecular mechanisms beyond the conventional antigen-presenting role of class I HLA molecules may contribute to the observed influence of

Indexed as

HIV-1HIV SeropositivityAllelesDNA-Binding ProteinsGenome-Wide Association StudyHLA-B AntigensHumansMajor Histocompatibility ComplexTranscription FactorsDNA-Binding ProteinsHLA-B57 antigenHLA-B AntigensTranscription FactorsZBTB12 protein, humanAIDSelite controllersgeneticsGWAShaplotypeHIV-1MHCviral load

Identifiers

PMID38146367
PMCPMC10749428
OpenAlexW4389571465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.