Evidence map›Paper›PMID 38146239›Full record

ArticleJournal of cellular and molecular medicine2024

Gastrodin alleviates premature senescence of vascular endothelial cells by enhancing the Nrf2/HO-1 signalling pathway.

Pengfei Tong, Ke Tian, Jiajia Bi, Ruihua Wang, Zhengfeng Wang

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. P-Hydroxybenzaldehyde fromPharmaceuticals (Basel, Switzerland) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pengfei TongNeurosurgery Department, The Third People's Hospital of Henan Province, Zhongyuan District, Zhengzhou City, Henan Province, China.ORCID 0009-0004-3411-0766
Ke TianNuclear Medicine Department, The First Affiliated Hospital of Zhengzhou University, Erqi District, Zhengzhou City, Henan Province, China.
Jiajia BiNeurosurgery Department, The First Affiliated Hospital of Zhengzhou University, Erqi District, Zhengzhou City, Henan Province, China.
Ruihua WangNuclear Medicine Department, The First Affiliated Hospital of Zhengzhou University, Erqi District, Zhengzhou City, Henan Province, China.
Zhengfeng WangNeurosurgery Department, The First Affiliated Hospital of Zhengzhou University, Erqi District, Zhengzhou City, Henan Province, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

Science and Technology Department of Henan Province 222102310028
6 · The paper itself

Abstract

Endothelial dysfunction is an independent risk factor for stroke. The dysfunction of endothelial cells (EC) is closely concerned with EC senescence. Gastrodin (GAS) is an organic compound extracted from the dried root mass of the Orchidaceae plant Gastrodiae gastrodiae. It is used clinically to treat diseases such as vertebrobasilar insufficiency, vestibular neuronitis and vertigo. In the present study, we used hydrogen peroxide (H

Indexed as

Benzyl AlcoholsGlucosidesNF-E2-Related Factor 2StrokeCellular SenescenceHumansHuman Umbilical Vein Endothelial CellsBenzyl AlcoholsgastrodinGlucosidesNF-E2-Related Factor 2cell senescencecerebrovascular diseasegastrodinNrf2/HO-1oxidative stressproliferation

Identifiers

PMID38146239
PMCPMC10844697
OpenAlexW4390235408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.