Evidence map›Paper›PMID 38146099›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Post-translational modifications linked to preclinical Alzheimer's disease-related pathological and cognitive changes.

Olamide Abiose, Jarod Rutledge, Patricia Moran-Losada, Michael E Belloy, Edward N Wilson, Zihuai He, Alexandra N Trelle, Divya Channappa, America Romero, Jennifer Park and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Roles of the E3 Ubiquitin Ligase TRIM47 in Inflammation, Organ Injury, and Cancer.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  2. Article
  3. Distinct regional vulnerability to Aβ and iron accumulation in post mortem AD brains.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Olamide AbioseDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.ORCID 0000-0003-2577-4152
Jarod RutledgeThe Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA.
Patricia Moran-LosadaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Michael E BelloyDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Edward N WilsonDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Zihuai HeDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Alexandra N TrelleDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Divya ChannappaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
America RomeroDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Jennifer ParkDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Maya V YutsisDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Sharon J ShaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Katrin I AndreassonDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Kathleen L PostonDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Victor W HendersonDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Anthony D WagnerWu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, California, USA.
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Elizabeth C MorminoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Stanford University · USNeurosciences Institute · USStanford Medicine · US

Funding

Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI Victor Henderson · 2020 to 2026
$29.0M
Working Memory in Parkinson Disease: A Cognitive & Systems Neuroscience ApproachP50AG047366 · NIA · STANFORD UNIVERSITY · PI HENDERSON, VICTOR · 2015 to 2019
$7.9M
Hippocampal-dependent memory decline in aging and early Alzheimer's diseaseR01AG074339 · NIA · STANFORD UNIVERSITY · PI ELIZABETH MORMINO · 2022 to 2026
$6.0M
High-resolution imaging of hippocampal mechanisms in age-related memory decline.R01AG048076 · NIA · STANFORD UNIVERSITY · PI WAGNER, ANTHONY D · 2014 to 2018
$1.9M
Elucidating sex-specific risk for Alzheimer's disease through state-of-the-art genetics and multi-omicsR00AG075238 · NIA · WASHINGTON UNIVERSITY · PI BELLOY, MICHAEL · 2024 to 2025
$727k
Elucidating sex-specific risk for Alzheimer's disease through state-of-the-art genetics and multi-omicsK99AG075238 · NIA · STANFORD UNIVERSITY · PI BELLOY, MICHAEL · 2022 to 2023
$264k
NIA NIH HHS K99 AG075238NIA NIH HHS K99AG075238NIA NIH HHS P30 AG066515NIA NIH HHS P30AG066515NIA NIH HHS P50 AG047366NIA NIH HHS P50AG047366NIA NIH HHS R00 AG075238NIA NIH HHS R01 AG048076NIA NIH HHS R01AG048076NIA NIH HHS R01 AG074339NIA NIH HHS R01AG74339
6 · The paper itself

Abstract

introductionIn this study, we leverage proteomic techniques to identify communities of proteins underlying Alzheimer's disease (AD) risk among clinically unimpaired (CU) older adults.

methodsWe constructed a protein co-expression network using 3869 cerebrospinal fluid (CSF) proteins quantified by SomaLogic, Inc., in a cohort of participants along the AD clinical spectrum. We then replicated this network in an independent cohort of CU older adults and related these modules to clinically-relevant outcomes.

resultsWe discovered modules enriched for phosphorylation and ubiquitination that were associated with abnormal amyloid status, as well as p-tau DISCUSSION: In leveraging CSF proteomic data from individuals spanning the clinical spectrum of AD, we highlight the importance of post-translational modifications for early cognitive and pathological changes.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedAmyloid beta-PeptidesBiomarkersCognitionHumansProtein Processing, Post-TranslationalProteomicstau ProteinsAmyloid beta-PeptidesBiomarkerstau ProteinsagingAlzheimer's diseaseautophagycerebral spinal fluidclinically unimpairedprotein co-expression networkubiquitination

Identifiers

PMID38146099
PMCPMC10984434
OpenAlexW4390234908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.