Evidence map›Paper›PMID 38146040›Full record

ArticleThe European journal of health economics : HEPAC : health economics in prevention and care2024

Impact of Long COVID on productivity and informal caregiving.

Joseph Kwon, Ruairidh Milne, Clare Rayner, Román Rocha Lawrence, Jordan Mullard, Ghazala Mir, Brendan Delaney, Manoj Sivan, Stavros Petrou

Open access · hybridAbstract read
In one paragraph

Article in The European journal of health economics : HEPAC : health economics in prevention and care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Exploring the influence of long COVID upon self-identity: a systematic literature review.Archives of public health = Archives belges de sante publique · 2026
    Pooled it
  2. Pooled it
  3. Cost-Effectiveness of a Personalised Self-Management Intervention for People Living With Long Covid: The LISTEN Randomised Controlled Trial.Health expectations : an international journal of public participation in health care and health policy · 2025
    Trial
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  7. Article
  8. Article
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  12. 'What Do People With Long Covid Want From Healthcare Services?' A Qualitative Exploration From Lived Experience.Health expectations : an international journal of public participation in health care and health policy · 2026
    Article
  13. Health economic outcomes and national economic impacts associated with Long COVID in England and Scotland.The European journal of health economics : HEPAC : health economics in prevention and care · 2026
    Article
  14. Article
  15. Article
  16. Systematic Review of Randomized Clinical Trials for the Treatment of Long COVID Syndrome.Journal of community hospital internal medicine perspectives · 2026
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  18. Review
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  20. Addressing Inequalities in Long Covid Healthcare: A Mixed-Methods Study on Building Inclusive Services.Health expectations : an international journal of public participation in health care and health policy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Joseph KwonNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England. joseph.kwon@phc.ox.ac.uk.ORCID http://orcid.org/0000-0002-2860-7280
Ruairidh MilnePublic Health, Wessex Institute, University of Southampton, Southampton, England.ORCID http://orcid.org/0000-0002-5117-4380
Clare RaynerLocomotion Patient Advisory Group (Co-Lead), University of Leeds, Leeds, England.ORCID http://orcid.org/0000-0002-5167-6903
Román Rocha Lawrence, ELAROS 24/7 Ltd, Sheffield, England.ORCID http://orcid.org/0000-0002-1913-9825
Jordan MullardSchool of Medicine, University of Leeds, Leeds, England.ORCID http://orcid.org/0000-0003-2712-6626
Ghazala MirSchool of Medicine, University of Leeds, Leeds, England.ORCID http://orcid.org/0000-0002-5277-6885
Brendan DelaneyDepartment of Surgery and Cancer, Imperial College London, London, England.ORCID http://orcid.org/0000-0002-3518-0131
Manoj SivanAcademic Department of Rehabilitation Medicine, University of Leeds, Leeds, England.ORCID http://orcid.org/0000-0002-0334-2968
Stavros PetrouNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England.ORCID http://orcid.org/0000-0003-3121-6050
University of Leeds · GBUniversity of Oxford · GBImperial College London · GBUniversity of Sheffield · GBUniversity of Southampton · GB

Funding

National Institute for Health and Care Research COV-LT2-0016
6 · The paper itself

Abstract

backgroundAround 2 million people in the UK suffer from Long COVID (LC). Of concern is the disease impact on productivity and informal care burden. This study aimed to quantify and value productivity losses and informal care receipt in a sample of LC patients in the UK.

methodsThe target population comprised LC patients referred to LC specialist clinics. The questionnaires included a health economics questionnaire (HEQ) measuring productivity impacts, informal care receipt and service utilisation, EQ-5D-5L, C19-YRS LC condition-specific measure, and sociodemographic and COVID-19 history variables. Outcomes were changes from the incident infection resulting in LC to the month preceding the survey in paid work status/h, work income, work performance and informal care receipt. The human capital approach valued productivity losses; the proxy goods method valued caregiving hours. The values were extrapolated nationally using published prevalence data. Multilevel regressions, nested by region, estimated associations between the outcomes and patient characteristics.

results366 patients responded to HEQ (mean LC duration 449.9 days). 51.7% reduced paid work hours relative to the pre-infection period. Mean monthly work income declined by 24.5%. The average aggregate value of productivity loss since incident infection was £10,929 (95% bootstrap confidence interval £8,844-£13,014) and £5.7 billion (£3.8-£7.6 billion) extrapolated nationally. The corresponding values for informal caregiving were £8,726 (£6,247-£11,204) and £4.8 billion (£2.6-£7.0 billion). Multivariate analyses found significant associations between each outcome and health utility and C19-YRS subscale scores.

conclusionLC significantly impacts productivity losses and provision of informal care, exacerbated by high national prevalence of LC.

Indexed as

CaregiversCOVID-19EfficiencyAdultAgedCost of IllnessFemaleHumansMaleMiddle AgedSARS-CoV-2Surveys and QuestionnairesUnited KingdomHealth economic evaluationInformal caregiver burdenLong COVIDProductivity

Identifiers

PMID38146040
PMCPMC11377524
OpenAlexW4390227275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.