Evidence map›Paper›PMID 38146016›Full record

ArticlePediatric blood & cancer2024

Role of non-chromosomal birth defects on the risk of developing childhood Hodgkin lymphoma: A Children's Oncology Group study.

Erin C Peckham-Gregory, Lucas Maschietto Boff, Jeremy M Schraw, Logan G Spector, Amy M Linabery, Erik B Erhardt, Karina B Ribeiro, Carl E Allen, Michael E Scheurer, Philip J Lupo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric blood & cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 68% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Erin C Peckham-GregoryDepartment of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-7593-8381
Lucas Maschietto BoffDepartment of Pediatrics, Center for Epidemiology and Population Health, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA.
Jeremy M SchrawDepartment of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA.
Logan G SpectorDivision of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Amy M LinaberyDepartment of Pediatrics, Neuroscience Institute, Children's Minnesota, Minneapolis, Minnesota, USA.
Erik B ErhardtDepartment of Mathematics and Statistics, University of New Mexico, Albuquerque, New Mexico, USA.ORCID https://orcid.org/0000-0002-9817-4011
Karina B RibeiroDepartment of Collective Health, Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-8095-5979
Carl E AllenDepartment of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA.
Michael E ScheurerDepartment of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA.
Philip J LupoDepartment of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-0978-5863
Baylor College of Medicine · USChildren's Minnesota · USFaculdade de Ciências Médicas da Santa Casa de São Paulo · BRUniversity of Minnesota · USUniversity of New Mexico · US

Funding

Tissue ResourceP50CA126752 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MALCOLM K. BRENNER, HELEN E HESLOP · 2007 to 2026
$51.4M
Integrating Epidemiologic and Genomic Data to Elucidate the Genetic Overlap Between Congenital Anomalies and Pediatric CancerR01CA284531 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Chad Daniel Huff, Philip Lupo · 2023 to 2026
$1.9M
Deep Phenotyping Children with Congenital Anomalies and Cancer Enrolled in Project:EveryChildR03CA272955 · NCI · BAYLOR COLLEGE OF MEDICINE · PI HEATH, ALLISON, LUPO, PHILIP · 2022 to 2023
$345k
NCI NIH HHS 1R03CA272955-01NCI NIH HHS P50 CA126752NCI NIH HHS P50 CA126752-13NCI NIH HHS R01 CA284531NCI NIH HHS R01CA284531NCI NIH HHS R03 CA272955
6 · The paper itself

Abstract

backgroundNon-chromosomal birth defects are an important risk factor for several childhood cancers. However, these associations are less clear for Hodgkin lymphoma (HL). Therefore, we sought to more fully elucidate the association between non-chromosomal birth defects and HL risk. PROCEDURE: Information on cases (n = 517) diagnosed with HL (ages of 0-14) at Children's Oncology Group Institutions for the period of 1989-2003 was obtained. Control children without a history of cancer (n = 784) were identified using random digit dialing and individually matched to cases on sex, race/ethnicity, age, and geographic location. Parents completed comprehensive interviews and answered questions including whether their child had been born with a non-chromosomal birth defect. To test the association between birth defects and HL risk, conditional logistic regression was applied to generate adjusted odds ratios (aORs) and 95% confidence intervals (CIs).

resultsChildren born with any non-chromosomal birth defect were not more likely to be diagnosed with HL at 0-14 years of age (aOR: 0.91; 95% CI: 0.69-1.21). No associations were detected between major or minor birth defects and HL (aOR: 1.34; 95% CI: 0.67-2.67 and aOR: 0.88; 95% CI: 0.57-1.34, respectively). Similarly, no association was observed for children born with any birth defect and EBV-positive HL (aOR: 0.57; 95% CI: 0.25-1.26).

conclusionsPrevious assessments of HL in children with non-chromosomal birth defects have been limited. Using data from the largest case-control study of HL in those <15 years of age, we did not observe strong associations between being born with a birth defect and HL risk.

Indexed as

Hodgkin DiseaseCase-Control StudiesChildEthnicityExtremitiesFemaleHumansMaleRisk Factorsbirth defectschildhoodepidemiologyHodgkin lymphomarisk factors

Identifiers

PMID38146016
PMCPMC12091268
OpenAlexW4390235708

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.