Evidence map›Paper›PMID 38145999›Full record

ArticleBasic research in cardiology2024

Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes.

Gu Li, He Huang, Yanshuang Wu, Chang Shu, Narae Hwang, Qifei Li, Rose Zhao, Hilaire C Lam, William M Oldham, Souheil Ei-Chemaly and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic research in cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Gu LiDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, 02115, USA.
He HuangDepartment of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China.
Yanshuang WuDivision of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Chang ShuDepartment of Cardiology, and Department of Pulmonary, Children's Hospital, Chongqing Medical University, Chongqing, 400015, China.
Narae HwangDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Qifei LiDivision of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, 02115, USA.
Rose ZhaoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Hilaire C LamDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
William M OldhamDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Souheil Ei-ChemalyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Pankaj B AgrawalDivision of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, 02115, USA.
Jie TianDepartment of Cardiology, and Department of Pulmonary, Children's Hospital, Chongqing Medical University, Chongqing, 400015, China.
Xiaoli Liu *Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, 02115, USA. xlliu@rics.bwh.harvard.edu.ORCID 0000-0003-2904-4413
Mark A Perrella *Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Brigham and Women's Hospital · USBoston Children's Hospital · USChildren's Hospital of Chongqing Medical University · CN

Funding

Mechanotransduction and YAP/TAZ Signaling in Pulmonary Arterial HypertensionR01HL137366 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PERRELLA, MARK A, TSCHUMPERLIN, DANIEL J. · 2018 to 2021
$2.7M
Cardiomyocyte Differentiation Regulates Cardiac FunctionR01HL102897 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PERRELLA, MARK A · 2011 to 2014
$1.7M
NHLBI NIH HHS R01HL102897NHLBI NIH HHS R01 HL137366NHLBI NIH HHS R01HL137366
6 · The paper itself

Abstract

A deficiency of striated preferentially expressed gene (Speg), a member of the myosin light chain kinase family, results in abnormal myofibril structure and function of immature cardiomyocytes (CMs), corresponding with a dilated cardiomyopathy, heart failure and perinatal death. Mitochondrial development plays a role in cardiomyocyte maturation. Therefore, this study investigated whether Speg deficiency ( - / - ) in CMs would result in mitochondrial abnormalities. Speg wild-type and Speg

Indexed as

Cardiomyopathy, DilatedMitochondrial DiseasesAdenosine TriphosphateAnimalsDNA, MitochondrialFemaleMiceMice, Inbred C57BLMuscle ProteinsMyocytes, CardiacMyosin-Light-Chain KinasePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPregnancyAdenosine TriphosphateDNA, MitochondrialMuscle ProteinsMyosin-Light-Chain KinasePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaSpeg protein, mouseDilated cardiomyopathyMitochondriaPGC-1α phosphorylationSpeg

Identifiers

PMID38145999
PMCPMC10837246
OpenAlexW4390237220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.