Evidence map›Paper›PMID 38145988›Full record

ArticleCommunications biology2023

ppGpp accumulation reduces the expression of the global nitrogen homeostasis-modulating NtcA regulon by affecting 2-oxoglutarate levels.

Ryota Hidese, Ryudo Ohbayashi, Yuichi Kato, Mami Matsuda, Kan Tanaka, Sousuke Imamura, Hiroki Ashida, Akihiko Kondo, Tomohisa Hasunuma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Suppressor analysis inFrontiers in microbiology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ryota HideseGraduate School of Science, Innovation and Technology, Kobe University, 1-1 Rokkodai, Nada, Kobe, 657-8501, Japan.
Ryudo OhbayashiLaboratory for Chemistry and Life Science Institute of Innovative Research, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan.
Yuichi KatoEngineering Biology Research Center, Kobe University, 1-1 Rokkodai, Nada, Kobe, 657-8501, Japan.ORCID 0000-0001-7670-9356
Mami MatsudaGraduate School of Science, Innovation and Technology, Kobe University, 1-1 Rokkodai, Nada, Kobe, 657-8501, Japan.
Kan TanakaLaboratory for Chemistry and Life Science Institute of Innovative Research, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan.
Sousuke ImamuraLaboratory for Chemistry and Life Science Institute of Innovative Research, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan.
Hiroki AshidaGraduate School of Human Development and Environment, Kobe University, 3-11 Tsurukabuto, Nada-Ku, Kobe, 657-8501, Japan.
Akihiko KondoGraduate School of Science, Innovation and Technology, Kobe University, 1-1 Rokkodai, Nada, Kobe, 657-8501, Japan.ORCID 0000-0003-1527-5288
Tomohisa HasunumaGraduate School of Science, Innovation and Technology, Kobe University, 1-1 Rokkodai, Nada, Kobe, 657-8501, Japan. hasunuma@port.kobe-u.ac.jp.ORCID 0000-0002-8382-2362
Kobe University · JPTokyo Institute of Technology · JPRIKEN Center for Sustainable Resource Science · JP

Funding

MEXT | Japan Science and Technology Agency (JST) JPMJMI19E4
6 · The paper itself

Abstract

The cyanobacterium Synechococcus elongatus PCC 7942 accumulates alarmone guanosine tetraphosphate (ppGpp) under stress conditions, such as darkness. A previous study observed that artificial ppGpp accumulation under photosynthetic conditions led to the downregulation of genes involved in the nitrogen assimilation system, which is activated by the global nitrogen regulator NtcA, suggesting that ppGpp regulates NtcA activity. However, the details of this mechanism have not been elucidated. Here, we investigate the metabolic responses associated with ppGpp accumulation by heterologous expression of the ppGpp synthetase RelQ. The pool size of 2-oxoglutarate (2-OG), which activates NtcA, is significantly decreased upon ppGpp accumulation. De novo

Indexed as

Guanosine TetraphosphateKetoglutaric AcidsHomeostasisNitrogenRegulonGuanosine TetraphosphateKetoglutaric AcidsNitrogen

Identifiers

PMID38145988
PMCPMC10749895
OpenAlexW4390186913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.