Evidence map›Paper›PMID 38145792›Full record

ArticleMicrobial pathogenesis2024

Systematic identification and characterization of five transcription factors mediating the oxidative stress response in Candida albicans.

Yingchao Cui, Daosheng Wang, Clarissa J Nobile, Danfeng Dong, Qi Ni, Tongxuan Su, Cen Jiang, Yibing Peng

Open access · greenAbstract read
In one paragraph

Article in Microbial pathogenesis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. A roadmap to chemically reactive species: how diverse oxidants affectMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  6. DVL, a Lectin fromAntibiotics (Basel, Switzerland) · 2025
    Article
  7. The regulatory network ofMicrobiology spectrum · 2025
    Article
  8. Microorganisms · 2025
    Article
  9. Unravelling the Role ofAntioxidants (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yingchao CuiDepartment of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Daosheng WangDepartment of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Clarissa J NobileDepartment of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, Merced, CA, USA; Health Sciences Research Institute, University of California, Merced, CA, USA.
Danfeng DongDepartment of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qi NiDepartment of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tongxuan SuDepartment of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cen JiangDepartment of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: jceasy@126.com.
Yibing PengDepartment of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: pyb9861@sina.com.
Shanghai Jiao Tong University · CNUniversity of California, Merced · US

Funding

Genetic regulation of inter- and intra-species microbial community formationR35GM124594 · NIGMS · UNIVERSITY OF CALIFORNIA, MERCED · PI NOBILE, CLARISSA JANE · 2017 to 2021
$2.0M
NIGMS NIH HHS R35 GM124594
6 · The paper itself

Abstract

Candida albicans is an opportunistic human fungal pathogen that causes superficial and systemic infections, particularly in immunocompromised individuals. In response to C. albicans infection, innate immune cells of the host produce and accumulate reactive oxygen species (ROS), which can lead to irreversible damage and apoptosis of fungal cells. Several transcription factors involved in this oxidative stress response have been identified; however, a systematic study to identify the transcription factors that mediate the oxidative stress response has not yet been conducted. Here, we screened a comprehensive transcription factor mutant library consisting of 211 transcription factor deletion mutant strains in the presence and absence of hydrogen peroxide (H

Indexed as

Candida albicansTranscription FactorsFungal ProteinsGene Expression Regulation, FungalHumansHydrogen PeroxideOxidative StressReactive Oxygen SpeciesFungal ProteinsHydrogen PeroxideReactive Oxygen SpeciesTranscription FactorsCandida albicansHydrogen peroxideOxidative stress responseROSTranscriptional profilingTranscription factors

Identifiers

PMID38145792
PMCPMC10872297
OpenAlexW4390146061

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.