Evidence map›Paper›PMID 38145296›Full record

ArticleAmerican journal of physiology. Cell physiology2024

Increased ENaC-mediated liquid absorption across vitamin-D deficient human airway epithelia.

Emma M Stapleton, Andrew L Thurman, Alejandro A Pezzulo, Alejandro P Comellas, Ian M Thornell

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Hyperconcentrated mucus in small airways: a mechanistic model for the pathogenesis of paediatric bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Emma M StapletonDivision of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0003-4565-094X
Andrew L ThurmanDivision of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0002-7777-4165
Alejandro A PezzuloDivision of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0001-7544-5109
Alejandro P ComellasDivision of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0003-1521-7520
Ian M ThornellDivision of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0001-5535-2925
University of Iowa · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Epigenetic mechanisms of inflammatory memory propagation in human airway epitheliaR01HL163024 · NHLBI · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 2022 to 2026
$2.8M
Heat-shock protein 90 modulates goblet cell metaplasia in human airway epitheliaK01HL140261 · NHLBI · UNIVERSITY OF IOWA · PI PEZZULO, ALEJANDRO ANTONIO · 2019 to 2023
$746k
NHLBI NIH HHS K01 HL140261NHLBI NIH HHS R01 HL163024NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Vitamin D deficiency is a risk factor for exacerbation of obstructive airway disease, a hallmark of which is mucus dehydration and plugging. Calcitriol (the active form of vitamin D) deficiency in cultured human airway epithelia resulted in increased

Indexed as

AmilorideVitamin D DeficiencyCalcitriolEpithelial Sodium ChannelsHumansLungRNA, MessengerVitamin DVitaminsAmilorideCalcitriolEpithelial Sodium ChannelsRNA, MessengerVitamin DVitaminsairwaycalcitriolENaCion transportvitamin-D

Identifiers

PMID38145296
PMCPMC11932534
OpenAlexW4390196734

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.