Evidence map›Paper›PMID 38144948›Full record

ArticlePulmonary circulation2023

Real-world evidence to advance knowledge in pulmonary hypertension: Status, challenges, and opportunities. A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative's Real-world Evidence Working Group.

Kellie Morland, Christian Gerges, Jean Elwing, Scott H Visovatti, Jason Weatherald, Kari R Gillmeyer, Sandeep Sahay, Stephen C Mathai, Athénaïs Boucly, Paul G Williams and 21 more

Open access · goldAbstract read
In one paragraph

Article in Pulmonary circulation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 20 institutions in 13 countries.

Kellie MorlandGlobal Medical Affairs United Therapeutics Corporation Research Triangle Park North Carolina USA.ORCID https://orcid.org/0000-0003-1800-7983
Christian GergesDepartment of Internal Medicine II, Division of Cardiology Medical University of Vienna Vienna Austria.
Jean ElwingDivision of Pulmonary, Critical Care, and Sleep Medicine University of Cincinnati Cincinnati Ohio USA.
Scott H VisovattiDivision of Cardiovascular Medicine The Ohio State University Columbus Ohio USA.
Jason WeatheraldDepartment of Medicine, Division of Pulmonary Medicine University of Alberta Edmonton Canada.
Kari R GillmeyerThe Pulmonary Center Boston University Chobian & Avedisian School of Medicine Boston Massachusetts USA.ORCID https://orcid.org/0000-0002-5333-259X
Sandeep SahayDivision of Pulmonary, Critical Care & Sleep Medicine Houston Methodist Hospital Houston Texas USA.ORCID https://orcid.org/0000-0002-0672-1680
Stephen C MathaiDivision of Pulmonary and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA.
Athénaïs BouclyFaculté de Médecine Université Paris-Saclay Le Kremlin-Bicêtre France.
Paul G WilliamsCenter of Chest Diseases & Critical Care Milpark Hospital Johannesburg South Africa.
Sivadasanpillai HarikrishnanSree Chitra Tirunal Institute for Medical Sciences and Technology Trivandrum Kerala India.
Evan P MintyDepartment of Medicine & O'Brien Institute for Public Health University of Calgary Calgary Canada.
Lukas HobohmDepartment of Cardiology University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany.ORCID https://orcid.org/0000-0002-4312-0366
Arun JoseDivision of Pulmonary, Critical Care, and Sleep Medicine University of Cincinnati Cincinnati Ohio USA.
Roberto BadagliaccaDepartment of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome Policlinico Umberto I Rome Italy.
Edmund M T LauDepartment of Respiratory Medicine, Royal Prince Alfred Hospital University of Sydney Camperdown New South Wales Australia.
Zhi-Cheng JingState Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.ORCID https://orcid.org/0000-0003-0493-0929
Rebecca R VanderpoolDivision of Cardiovascular Medicine The Ohio State University Columbus Ohio USA.
Charles FauvelService de Cardiologie, Centre de Compétence en Hypertension Pulmonaire 27/76, Centre Hospitalier Universitaire Charles Nicolle, INSERM EnVI U1096 Université de Rouen Rouen France.
Jose Leonidas AlvesPulmonary Division, Heart Institute University of São Paulo Medical School São Paulo Brazil.
Geoff StrangeSchool of Medicine The University of Notre Dame Australia Perth Western Australia Australia.
Tomas PulidoIgnacio Chávez National Heart Institute México City Mexico.
Junyan QianDepartment of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing China.
Mengtao LiDepartment of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology Ministry of Education Beijing China.
Valentina MercurioDepartment of Translational Medical Sciences Federico II University Naples Italy.
Jason G E ZeltDepartment of Medicine, Faculty of Medicine University of Ottawa Ottawa Canada.
Victor M MolesDivision of Cardiovascular Medicine University of Michigan Ann Arbor Michigan USA.
Meghan M CirulisDivision of Pulmonary and Critical Care Medicine University of Utah Salt Lake City Utah USA.
Sylvia M NikkhoGlobal Clinical Development Bayer AG Berlin Germany.ORCID https://orcid.org/0000-0003-1245-2656
Raymond L BenzaMount Sinai Heart Icahn School of Medicine at Mount Sinai New York New York USA.ORCID https://orcid.org/0000-0001-9627-6236
C Gregory ElliottDivision of Pulmonary and Critical Care Medicine University of Utah Salt Lake City Utah USA.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNThe Ohio State University · USUniversity of Cincinnati · USUniversity of Utah · USBayer (Germany) · DEBoston University · USFederico II University Hospital · ITHouston Methodist · USIcahn School of Medicine at Mount Sinai · USInserm · FRInstituto Nacional de Cardiología · MXJohannes Gutenberg University Mainz · DEJohns Hopkins University · USMedical University of Vienna · ATMilpark Hospital · ZAPoliclinico Umberto I · ITSree Chitra Thirunal Institute for Medical Sciences and Technology · INThe University of Notre Dame Australia · AUThe University of Sydney · AUTriangle · US

Funding

Biomarker Discovery in Portopulmonary HypertensionK23HL164971 · NHLBI · UNIVERSITY OF CINCINNATI · PI Arun Jose · 2023 to 2026
$822k
NHLBI NIH HHS K23 HL164971
6 · The paper itself

Abstract

This manuscript on real-world evidence (RWE) in pulmonary hypertension (PH) incorporates the broad experience of members of the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative Real-World Evidence Working Group. We aim to strengthen the research community's understanding of RWE in PH to facilitate clinical research advances and ultimately improve patient care. Herein, we review real-world data (RWD) sources, discuss challenges and opportunities when using RWD sources to study PH populations, and identify resources needed to support the generation of meaningful RWE for the global PH community.

Indexed as

administrative claims dataelectronic health recordspatient‐generated health datareal‐world dataregistries

Identifiers

PMID38144948
PMCPMC10739115
OpenAlexW4390117293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.