ArticleNetwork neuroscience (Cambridge, Mass.)2023
The human brain connectome weighted by the myelin content and total intra-axonal cross-sectional area of white matter tracts.
Article in Network neuroscience (Cambridge, Mass.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Anatomical white matter tracts span the cortical hierarchy to support cognitive diversity.Nature human behaviour · 2026Article
- The microstructure-weighted human connectome: network properties and structure-function correlations across spatial scales.bioRxiv : the preprint server for biology · 2026Article
- The role of white matter myelin in structural-functional network coupling.Communications biology · 2026Article
- Human cortical dynamics reflect graded contributions of local geometry and network topography.Nature communications · 2025Article
- Anatomical White Matter Tracts Span the Cortical Hierarchy to Support Cognitive Diversity.bioRxiv : the preprint server for biology · 2025Article
- Linking Individual Variability of Multi-modal Connectivity, Lifestyle, Psycho-Social Factors and Cognition in Older Adults.Aging and disease · 2025Article
- Mapping the aggregate g-ratio of white matter tracts using multi-modal MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Regularized partial correlation provides reliable functional connectivity estimates while correcting for widespread confounding.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A simulated annealing algorithm for randomizing weighted networks.Nature computational science · 2025Article
- Weighting the structural connectome: Exploring its impact on network properties and predicting cognitive performance in the human brain.Network neuroscience (Cambridge, Mass.) · 2024Article
- Constructing representative group networks from tractography: lessons from a dynamical approach.Frontiers in network physiology · 2024Article
- Integrating multimodal and multiscale connectivity blueprints of the human cerebral cortex in health and disease.PLoS biology · 2023Article
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A central goal in neuroscience is the development of a comprehensive mapping between structural and functional brain features, which facilitates mechanistic interpretation of brain function. However, the interpretability of structure-function brain models remains limited by a lack of biological detail. Here, we characterize human structural brain networks weighted by multiple white matter microstructural features including total intra-axonal cross-sectional area and myelin content. We report edge-weight-dependent spatial distributions, variance, small-worldness, rich club, hubs, as well as relationships with function, edge length, and myelin. Contrasting networks weighted by the total intra-axonal cross-sectional area and myelin content of white matter tracts, we find opposite relationships with functional connectivity, an edge-length-independent inverse relationship with each other, and the lack of a canonical rich club in myelin-weighted networks. When controlling for edge length, networks weighted by either fractional anisotropy, radial diffusivity, or neurite density show no relationship with whole-brain functional connectivity. We conclude that the co-utilization of structural networks weighted by total intra-axonal cross-sectional area and myelin content could improve our understanding of the mechanisms mediating the structure-function brain relationship.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.