Evidence map›Paper›PMID 38143903›Full record

ArticleEvolutionary applications2023

The evolution of resistance to synergistic multi-drug combinations is more complex than evolving resistance to each individual drug component.

Natalie Ann Lozano-Huntelman, Austin Bullivant, Jonathan Chacon-Barahona, Alondra Valencia, Nick Ida, April Zhou, Pooneh Kalhori, Gladys Bello, Carolyn Xue, Sada Boyd and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evolutionary applications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Natalie Ann Lozano-HuntelmanDepartment of Ecology and Evolutionary Biology University of California, Los Angeles Los Angeles California USA.ORCID https://orcid.org/0000-0001-8796-0001
Austin BullivantDepartment of Ecology and Evolutionary Biology University of California, Los Angeles Los Angeles California USA.
Jonathan Chacon-BarahonaDepartment of Ecology and Evolutionary Biology University of California, Los Angeles Los Angeles California USA.
Alondra ValenciaDepartment of Ecology and Evolutionary Biology University of California, Los Angeles Los Angeles California USA.
Nick IdaDepartment of Ecology and Evolutionary Biology University of California, Los Angeles Los Angeles California USA.
April ZhouDepartment of Ecology and Evolutionary Biology University of California, Los Angeles Los Angeles California USA.
Pooneh KalhoriDepartment of Ecology and Evolutionary Biology University of California, Los Angeles Los Angeles California USA.
Gladys BelloDepartment of Ecology and Evolutionary Biology University of California, Los Angeles Los Angeles California USA.
Carolyn XueDepartment of Ecology and Evolutionary Biology University of California, Los Angeles Los Angeles California USA.
Sada BoydDepartment of Ecology and Evolutionary Biology University of California, Los Angeles Los Angeles California USA.
Colin KremerDepartment of Ecology and Evolutionary Biology University of California, Los Angeles Los Angeles California USA.
Pamela J YehDepartment of Ecology and Evolutionary Biology University of California, Los Angeles Los Angeles California USA.
University of California, Los Angeles · USSanta Fe Institute · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Systems in Integrative BiologyT32GM008185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHOU, TOM · 1987 to 2022
$4.6M
NCATS NIH HHS UL1 TR001881NIGMS NIH HHS T32 GM008185
6 · The paper itself

Abstract

Multidrug antibiotic resistance is an urgent public health concern. Multiple strategies have been suggested to alleviate this problem, including the use of antibiotic combinations and cyclic therapies. We examine how adaptation to (1) combinations of drugs affects resistance to individual drugs, and to (2) individual drugs alters responses to drug combinations. To evaluate this, we evolved multiple strains of drug resistant

Indexed as

antibiotic combinationsantibiotic resistanceantimicrobialbacterial evolution

Identifiers

PMID38143903
PMCPMC10739078
OpenAlexW4388688842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.