ArticleMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine2025
Value of T1 Mapping in the Non-invasive Assessment of Renal Pathologic Injury for Chronic Kidney Disease Patients.
Article in Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 10 citations in OpenAlex.
- Value of multiparametric MRI as a potential marker to differentiate membranous nephropathy from IgA nephropathy.BMC medical imaging · 2026Article
- Multiparametric MR Imaging for Evaluating Renal Function and Microstructure.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Review
- Insight into Kidney Function and Microstructure Through Renal MRI-Review of the Literature.Bioengineering (Basel, Switzerland) · 2026Review
- Assessing kidney fibrosis via multiparametric MRI in native kidney and allografts.Clinical kidney journal · 2026Article
- Nomograms with arterial spin labeling for diagnosing early-stage chronic kidney disease.International urology and nephrology · 2026Article
- Quantitative assessment of renal function and perfusion changes in membranous nephropathy using multiparametric magnetic resonance imaging.Insights into imaging · 2026Article
- The role of texture analysis of T1 weighted images in diagnosis of chronic kidney disease.Scientific reports · 2026Article
- The Possibilities of Multiparametric Magnetic Resonance Imaging to Reflect Functional and Structural Graft Changes 1 Year After Kidney Transplantation.Medicina (Kaunas, Lithuania) · 2025Article
- T1 mapping magnetic resonance imaging predicts decline of kidney function.Clinical kidney journal · 2025Article
- Article
- Multi-parametric MRI-based machine learning model for prediction of pathological grade of renal injury in a rat kidney cold ischemia-reperfusion injury model.BMC medical imaging · 2024Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThe objective of this study was to evaluate renal function and pathologic injury in chronic kidney disease (CKD) using T1 mapping.
methodsWe recruited fifteen healthy volunteers (HV) and seventy-five CKD patients to undergo T1 mapping examination, and renal parenchymal T1 values were measured. Spearman correlation analysis was used to evaluate the relevance between the pathologic injury score, estimated glomerular filtration rate (eGFR), and renal parenchymal T1 values. The diagnostic efficiency of T1 value in evaluating renal pathologic impairment was assessed.
resultsIn all subjects, renal cortical T1 value was remarkably lower than renal medullary T1 value (P < 0.01). The renal medullary T1 value of HV was considerably lower than that of CKD patients in all stages (P < 0.05). The T1 values were negatively correlated with eGFR (cortex, r = -0.718; medulla, r = -0.645). The T1 values were positively correlated with glomerular injury score (cortex, r = 0.692; medulla, r = 0.632), tubulointerstitial injury score (cortex, r = 0.758; medulla, r = 0.690) (all P < 0.01). The area under the curve (AUC) of renal cortical and medullary T1 values were 0.914 and 0.880 to distinguish moderate-severe from mild renal injury groups. To differentiate mild renal injury group from control group, the AUC values of renal cortical and medullary T1 values were 0.879 and 0.856.
conclusionT1 mapping has potential application value in non-invasively assessing renal pathologic injury in CKD.
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