Evidence map›Paper›PMID 38142946›Full record

ArticleBiochimica et biophysica acta. Proteins and proteomics2024

Propagation of conformational instability in FK506-binding protein FKBP12.

David M LeMaster, Qamar Bashir, Griselda Hernández

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Proteins and proteomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 67% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

David M LeMasterBiggs Laboratory Wadsworth Center, NYS Department of Health, Empire State Plaza, Albany, NY 12237, United States of America.
Qamar BashirBiggs Laboratory Wadsworth Center, NYS Department of Health, Empire State Plaza, Albany, NY 12237, United States of America.
Griselda HernándezBiggs Laboratory Wadsworth Center, NYS Department of Health, Empire State Plaza, Albany, NY 12237, United States of America. Electronic address: griselda.hernandez@health.ny.gov.
Wadsworth Center · US

Funding

Coupled transitions of FK506-binding domains in molecular design and signalingR01GM119152 · NIGMS · WADSWORTH CENTER · PI HERNANDEZ, GRISELDA · 2017 to 2020
$1.2M
Upgrade of 800 MHz SpectrometerS10OD016432 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI PALMER, ARTHUR G · 2014 to 2014
$600k
NIGMS NIH HHS R01 GM119152NIH HHS S10 OD016432
6 · The paper itself

Abstract

FKBP12 is the archetype of the FK506 binding domains that define the family of FKBP proteins which participate in the regulation of various distinct physiological signaling processes. As the drugs FK506 and rapamycin inhibit many of these FKBP proteins, there is need to develop therapeutics which exhibit selectivity within this family. The long β

Indexed as

Tacrolimus Binding Protein 1ATacrolimus Binding ProteinsCatalytic DomainHydrogenTacrolimusHydrogenTacrolimusTacrolimus Binding Protein 1ATacrolimus Binding ProteinsConformational stabilityFK506-binding proteinsFKBP12Hydrogen exchangeInhibitor bindingProtein NMR

Identifiers

PMID38142946
PMCPMC10939819
OpenAlexW4390128856

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.