Evidence map›Paper›PMID 38142739›Full record

ReviewAdvanced drug delivery reviews2024

Translation of cell therapies to treat autoimmune disorders.

Jinal M Mehta, Shivani C Hiremath, Chishiba Chilimba, Azin Ghasemi, Jessica D Weaver

Open access · greenAbstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jinal M MehtaSchool of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.
Shivani C HiremathSchool of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.
Chishiba ChilimbaSchool of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.
Azin GhasemiSchool of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA.
Jessica D WeaverSchool of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA. Electronic address: jdweave5@asu.edu.
Arizona State University · US

Funding

Immunosuppression-free transplantation through placental mimicryDP2AI169476 · NIAID · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI WEAVER, JESSICA DIANE · 2021 to 2024
$2.4M
Optimizing macroencapsulation devices for islet transplantation via magnetic resonance oximetryR01DK129858 · NIDDK · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI KODIBAGKAR, VIKRAM D., WEAVER, JESSICA DIANE · 2021 to 2024
$1.4M
Immunosuppression-free islet transplantation via localized immunomodulatory exosome tetheringR21AI151865 · NIAID · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI WEAVER, JESSICA DIANE · 2022 to 2023
$408k
NIAID NIH HHS DP2 AI169476NIAID NIH HHS R21 AI151865NIDDK NIH HHS R01 DK129858
6 · The paper itself

Abstract

Autoimmune diseases are a diverse and complex set of chronic disorders with a substantial impact on patient quality of life and a significant global healthcare burden. Current approaches to autoimmune disease treatment comprise broadly acting immunosuppressive drugs that lack disease specificity, possess limited efficacy, and confer undesirable side effects. Additionally, there are limited treatments available to restore organs and tissues damaged during the course of autoimmune disease progression. Cell therapies are an emergent area of therapeutics with the potential to address both autoimmune disease immune dysfunction as well as autoimmune disease-damaged tissue and organ systems. In this review, we discuss the pathogenesis of common autoimmune disorders and the state-of-the-art in cell therapy approaches to (1) regenerate or replace autoimmune disease-damaged tissue and (2) eliminate pathological immune responses in autoimmunity. Finally, we discuss critical considerations for the translation of cell products to the clinic.

Indexed as

Autoimmune DiseasesQuality of LifeAutoimmunityCell- and Tissue-Based TherapyHumansImmunosuppressive AgentsImmunosuppressive AgentsAutoimmune diseaseCell therapyCell therapy translationRegenerative medicine

Identifiers

PMID38142739
PMCPMC10843859
OpenAlexW4390102485

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.