Evidence map›Paper›PMID 38142631›Full record

ArticleParkinsonism & related disorders2024

Hair color, family history of melanoma, and the risk of Parkinson's disease: An analysis update.

Mario H Flores-Torres, Kjetil Bjornevik, Xinyuan Zhang, Xiang Gao, Albert Y Hung, Michael A Schwarzschild, Xiqun Chen, Alberto Ascherio

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. medRxiv : the preprint server for health sciences · 2025
    Article
  3. Review
  4. The Skin-Brain Axis: From UV and Pigmentation to Behaviour Modulation.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mario H Flores-TorresDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: maflores@hsph.harvard.edu.
Kjetil BjornevikDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Xinyuan ZhangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Xiang GaoDepartment of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, Shanghai, China.
Albert Y HungMassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Michael A SchwarzschildMassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Xiqun ChenMassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
Alberto AscherioDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Harvard University · USBrigham and Women's Hospital · USFudan University · CN

Funding

Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
MC1R Basis of Melanoma-Parkinson's Link and Neuroprotective Potential of MC1RR01NS102735 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, XIQUN · 2018 to 2022
$1.8M
NCI NIH HHS U01 CA167552NCI NIH HHS UM1 CA186107NINDS NIH HHS R01 NS102735
6 · The paper itself

Abstract

backgroundA shared biological component between melanoma and Parkinson's disease (PD) has been suggested. Yet, epidemiological evidence is scarce.

objectiveTo examine the association of hair color and family history of melanoma, two strong predictors of melanoma risk, with the occurrence of PD.

methodsWe followed 131,342 women and men for ∼30 years for the development of PD. We calculated the cumulative incidence of PD from ages 40 to 90 according to hair color, and estimated the hazard ratio of PD according to hair color and family history of melanoma.

resultsHair color was not strongly associated with the risk of PD, especially at advanced ages. In contrast, individuals with a family history of melanoma had a 1.4-fold higher risk of PD compared to those without a history.

conclusionsOur results support the hypothesis of a shared biological component between PD and melanoma. Both pigmentary and non-pigmentary pathways may play a role.

Indexed as

MelanomaParkinson DiseaseFemaleHair ColorHumansIncidenceMaleRisk Factors

Identifiers

PMID38142631
PMCPMC10843649
OpenAlexW4390064865

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.