Evidence map›Paper›PMID 38142583›Full record

ArticleRedox biology2024

Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis.

Xue Yang, Chun Gu, Jingshu Cai, Feiyang Li, Xing He, Lunan Luo, Wengan Xiao, Boyan Hu, Jing Hu, Hao Qian and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 23 citations in OpenAlex.

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  13. Role of the transcription factorTranslational cancer research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Xue YangThe Sichuan Provincial Key Laboratory for Human Disease Gene, Study Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China; Laboratory of Ageing Research, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China.
Chun GuSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China; Department of Hepatobiliary & Pancreatic Center, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China; Department of Hepatobiliary & Pancreatic Center, Chinese Academy of Medical Sciences and Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan, 610072, China.
Jingshu CaiSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China; The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Feiyang LiLaboratory of Ageing Research, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China.
Xing HeThe Sichuan Provincial Key Laboratory for Human Disease Gene, Study Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China; Laboratory of Ageing Research, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China.
Lunan LuoLaboratory of Ageing Research, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China.
Wengan XiaoSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China.
Boyan HuSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China.
Jing HuThe Sichuan Provincial Key Laboratory for Human Disease Gene, Study Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China.
Hao QianThe Sichuan Provincial Key Laboratory for Human Disease Gene, Study Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China.
Shangqing RenSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China; Robotic Minimally Invasive Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610072, China.
Lin ZhangThe Sichuan Provincial Key Laboratory for Human Disease Gene, Study Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, 610072, China.
Xianjun ZhuThe Sichuan Provincial Key Laboratory for Human Disease Gene, Study Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, 610072, China.
Lu YangLaboratory of Ageing Research, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China.
Jing YangLaboratory of Ageing Research, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China.
Zhenglin YangThe Sichuan Provincial Key Laboratory for Human Disease Gene, Study Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan, 610072, China.
Yi ZhengLaboratory of Ageing Research, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China. Electronic address: yi_zheng@uestc.edu.cn.
Xiang HuangThe Sichuan Provincial Key Laboratory for Human Disease Gene, Study Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China; Department of Urology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Ziyan WangThe Sichuan Provincial Key Laboratory for Human Disease Gene, Study Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China; Laboratory of Ageing Research, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, China. Electronic address: ziyanwang@uestc.edu.cn.
University of Electronic Science and Technology of China · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CNThe Affiliated Yongchuan Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid peroxidation and redox imbalance are hallmarks of ferroptosis, an iron-dependent form of cell death. Growing evidence suggests that dysregulation in glycolipid metabolism and iron homeostasis substantially contribute to the development of hepatocellular carcinoma (HCC). However, there is still a lack of comprehensive understanding regarding the specific transcription factors that are capable of coordinating glycolipid and redox homeostasis to initiate the onset of ferroptosis. We discovered that overexpression of SOX8 leads to impaired mitochondria integrate, increased oxidative stress, and enhanced lipid peroxidation. These effects can be attributed to the inhibitory impact of SOX8 on de novo lipogenesis, glycolysis, the tricarboxylic acid cycle (TCA), and the pentose phosphate pathway (PPP). Additionally, upregulation of SOX8 results in reduced synthesis of NADPH, disturbance of redox homeostasis, disruption of mitochondrial structure, and impairment of the electron transport chain. Furthermore, the overexpression of SOX8 enhances the process of ferroptosis by upregulating the expression of genes associated with ferroptosis and elevating intracellular levels of ferrous ion. Importantly, the overexpressing of SOX8 has been observed to inhibit the proliferation of HCC in immunodeficient animal models. In conclusion, the findings suggest that SOX8 has the ability to alter glycolipid and iron metabolism of HCC cells, hence triggering the process of ferroptosis. The results of our study present a novel strategy for targeting ferroptosis in the therapy of HCC.

Indexed as

Carcinoma, HepatocellularFerroptosisLiver NeoplasmsAnimalsGlycolipidsIronGlycolipidsIronFerroptosisGlycolipid metabolismHCCIron metabolismSOX8

Identifiers

PMID38142583
PMCPMC10788634
OpenAlexW4389869321

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.