Evidence map›Paper›PMID 38141770›Full record

ArticleThe Journal of biological chemistry2024

Actin-binding protein profilin1 is an important determinant of cellular phosphoinositide control.

Morgan M C Ricci, Andrew Orenberg, Lee Ohayon, David Gau, Rachel C Wills, Yongho Bae, Tuhin Das, David Koes, Gerald R V Hammond, Partha Roy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Subcellular Cartography of the Phosphoinositide Multiverse.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2026
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Morgan M C RicciDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Andrew OrenbergDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lee OhayonDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
David GauDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rachel C WillsDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Yongho BaeDepartment of Pathology and Anatomical Science, University at Buffalo, Buffalo, New York, USA.
Tuhin DasTavotek Biotherapeutics, Spring House, Pennsylvania, USA.
David KoesDepartment of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Gerald R V HammondDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: ghammond@pitt.edu.
Partha RoyDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: par19@pitt.edu.
University of Pittsburgh · USSpringhouse · USUniversity at Buffalo, State University of New York · US

Funding

Cardiovascular Bioengineering Training ProgramT32HL076124 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANJEEV G SHROFF · 2005 to 2026
$7.0M
Training Program in Imaging Sciences in Translational Cardiovascular ResearchT32HL129964 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Flordeliza S Villanueva · 2016 to 2026
$4.7M
Directing Membrane Function with Inositol Lipids in Health and DiseaseR35GM119412 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gerald R Hammond · 2016 to 2026
$4.3M
Profilin biology in breast cancerR01CA248873 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROY, PARTHA · 2021 to 2025
$1.8M
Transcriptional Regulation of Dormancy and Emergence in Breast CancerR01CA271095 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PARTHA ROY · 2023 to 2026
$1.5M
Discovery of Cell-based Chemical Probes Targeting Aberrant Angiogenesis in the EyeR21EY032632 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HURYN, DONNA M, KOES, DAVID RYAN · 2022 to 2023
$426k
Profilin as a Novel Target for Vascular Normalization in Renal CancerK99CA267180 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAU, DAVID MARTIN · 2022 to 2023
$252k
NCI NIH HHS K99 CA267180NCI NIH HHS R01 CA248873NCI NIH HHS R01 CA271095NEI NIH HHS R21 EY032632NHLBI NIH HHS T32 HL076124NHLBI NIH HHS T32 HL129964NIGMS NIH HHS R35 GM119412
6 · The paper itself

Abstract

Membrane polyphosphoinositides (PPIs) are lipid-signaling molecules that undergo metabolic turnover and influence a diverse range of cellular functions. PPIs regulate the activity and/or spatial localization of a number of actin-binding proteins (ABPs) through direct interactions; however, it is much less clear whether ABPs could also be an integral part in regulating PPI signaling. In this study, we show that ABP profilin1 (Pfn1) is an important molecular determinant of the cellular content of PI(4,5)P

Indexed as

PhosphatidylinositolsProfilinsEpidermal Growth FactorHEK293 CellsHumansPhosphatidylinositol-3,4,5-Trisphosphate 5-PhosphatasesPhosphatidylinositol 3-KinasesEpidermal Growth FactorPFN1 protein, humanPhosphatidylinositol-3,4,5-Trisphosphate 5-PhosphatasesPhosphatidylinositol 3-KinasesPhosphatidylinositolsProfilinsphosphoinositidesPI(3,4,5)P(3)PI(3,4)P(2)PI(4,5)P(2)profilinSHIP2

Identifiers

PMID38141770
PMCPMC10826164
OpenAlexW4390064532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.