Evidence map›Paper›PMID 38141613›Full record

ArticleStructure (London, England : 1993)2024

Structural mechanism of TRPV5 inhibition by econazole.

José J De Jesús-Pérez, Matthew Gabrielle, Sumiyya Raheem, Edwin C Fluck, Tibor Rohacs, Vera Y Moiseenkova-Bell

Open access · bronzeAbstract read
In one paragraph

Article in Structure (London, England : 1993), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

José J De Jesús-PérezDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Matthew GabrielleDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA.
Sumiyya RaheemDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA.
Edwin C FluckDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Tibor RohacsDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA.
Vera Y Moiseenkova-BellDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: vmb@pennmedicine.upenn.edu.
Rutgers, The State University of New Jersey · USTranslational Therapeutics (United States) · US

Funding

Regulation of the Intestinal Ca2+ Channels TRPV6R01GM093290 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI CARNEVALE, VINCENZO, ROHACS, TIBOR · 2011 to 2025
$4.9M
Structure and Function of TRPV channelsR35GM144120 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Vera Moiseenkova-Bell · 2022 to 2026
$4.2M
NIGMS NIH HHS R01 GM093290NIGMS NIH HHS R35 GM144120
6 · The paper itself

Abstract

The calcium-selective TRPV5 channel activated by phosphatidylinositol 4,5-bisphosphate [PI(4,5)P

Indexed as

Antifungal AgentsEconazoleTRPV Cation ChannelsCalciumCryoelectron MicroscopyMolecular Dynamics SimulationAntifungal AgentsCalciumEconazoleTRPV Cation Channelsactivation by PI(4,5)P(2)cryo electron microscopycryo-EMECNgating mechanism inhibitioninhibition by econazoleTransient receptor potential channelTRP

Identifiers

PMID38141613
PMCPMC10872542
OpenAlexW4390116137

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.