Evidence map›Paper›PMID 38141157›Full record

ArticleGeroScience2024

The CEPH aging cohort and biobank: a valuable collection of biological samples from exceptionally long-lived French individuals and their offspring for longevity studies.

Alexandre How-Kit, Mourad Sahbatou, Lise M Hardy, Nicolas P Tessier, Valérie Schiavon, Hélène Le Buanec, Jean-Marc Sebaoun, Hélène Blanché, Jean-François Zagury, Jean-François Deleuze

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in GeroScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Alexandre How-KitLaboratory for Genomics, Foundation Jean Dausset - CEPH, Paris, France. alexandre.how-kit@fjd-ceph.org.ORCID 0000-0002-1584-9336
Mourad SahbatouLaboratory for Genomics, Foundation Jean Dausset - CEPH, Paris, France.
Lise M HardyLaboratory for Genomics, Foundation Jean Dausset - CEPH, Paris, France.
Nicolas P TessierLaboratory for Genomics, Foundation Jean Dausset - CEPH, Paris, France.
Valérie SchiavonINSERM U976 - HIPI Unit, Saint-Louis Research Institute, University of Paris, Paris, France.
Hélène Le BuanecINSERM U976 - HIPI Unit, Saint-Louis Research Institute, University of Paris, Paris, France.
Jean-Marc SebaounCentre de Ressources Biologiques, Foundation Jean Dausset - CEPH, Paris, France.
Hélène BlanchéLaboratory of Excellence GenMed, Paris, France.
Jean-François ZaguryÉquipe Génomique, Bioinformatique et Chimie Moléculaire (EA 7528), Conservatoire National Des Arts et Métiers, HESAM Université, Paris, France.
Jean-François DeleuzeLaboratory for Genomics, Foundation Jean Dausset - CEPH, Paris, France. deleuze@cnrgh.fr.
Fondation Jean Dausset-CEPH · FRInserm · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRHESAM Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing aging of the human population is currently and for the coming decades a major public health issue in many countries, requiring the implementation of global public health policies promoting healthy and successful aging. Individuals are not equal in the face of aging and some can present exceptional healthspan and/or lifespan, which are notably influenced by both genetic and environmental factors. Research and studies on human aging, healthy aging and longevity should rely in particular on cohorts of long-lived individuals, also including biological samples allowing studies on the biology of aging and longevity. In this manuscript, we provide for the first time a complete description of the CEPH (Centre d'Etude du Polymophisme Humain) Aging cohort, an exceptional cohort recruited during the 90s to 2000s, including more than 1700 French long-lived individuals (≥ 90 years old) born between 1875 and 1916 as well as for some of them their siblings and offspring. Among the participants, 1265 were centenarians, including 255 semi-supercentenarians ([105-110] years old) and 25 supercentenarians (≥ 110 years old). The available anthropometric, epidemiologic and clinical data for the cohort participants are described and especially the collection of blood-derived biological samples associated with the cohort which includes DNA, cryopreserved cells and cell lines, plasma, and serum. This biological collection from the first cohort of centenarians in the world is an inestimable resource for ongoing and future molecular, cellular, and functional studies aimed at deciphering the mechanisms of human (successful) aging and longevity.

Indexed as

Biological Specimen BanksLongevityAged, 80 and overAgingHealth StatusHumansLongitudinal StudiesAgingBiobanksBiorepositoryBlood samplesCentenariansCohort studyDNALongevity

Identifiers

PMID38141157
PMCPMC10828222
OpenAlexW4390144082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.