Evidence map›Paper›PMID 38141134›Full record

ArticleVirchows Archiv : an international journal of pathology2024

Analysis of GATA3 and FOXA2 expression suggests that downregulation of genes involved in the maintenance of a mature yolk sac tumor phenotype may underlie sarcomatoid transformation.

Costantino Ricci, Francesca Ambrosi, Alessia Grillini, Francesco Massari, Michelangelo Fiorentino, Maurizio Colecchia, Thomas M Ulbright, Andres Martin Acosta

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Costantino RicciPathology Unit, Maggiore Hospital-AUSL Bologna, Bologna, Italy. costantino.ricci4@unibo.it.ORCID http://orcid.org/0000-0001-7254-4195
Francesca AmbrosiPathology Unit, Maggiore Hospital-AUSL Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0001-9046-1115
Alessia GrilliniPathology Unit, Maggiore Hospital-AUSL Bologna, Bologna, Italy.
Francesco MassariDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.ORCID http://orcid.org/0000-0001-6476-6871
Michelangelo FiorentinoPathology Unit, Maggiore Hospital-AUSL Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0002-1749-150X
Maurizio ColecchiaVita-Salute San Raffaele University, Milan, Italy.ORCID http://orcid.org/0000-0003-1914-0743
Thomas M UlbrightDepartment of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA.
Andres Martin AcostaDepartment of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0003-0164-5911
Indiana University School of MedicineUniversity of Bologna · ITAzienda USL di Bologna · ITOspedale Maggiore Carlo Alberto Pizzardi · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the post-chemotherapy setting, germ cell tumors of the testis (GCTT) that resemble non-specific sarcomas and co-express cytokeratins and glypican-3 (GPC3) are diagnosed as "sarcomatoid yolk sac tumor postpubertal-type (YSTpt)". The diagnosis of sarcomatoid YSTpt is clinically relevant but challenging due to its rarity, non-specific histology, and negative α-fetoprotein (AFP) staining. Recently, FOXA2 has emerged as a key-gene in the reprogramming of GCTT (activating the transcription of several genes, among which GATA3), and immunohistochemical studies showed that GATA3 and FOXA2 have a higher sensitivity for non-sarcomatoid YSTpt than GPC3 and AFP. We found that sarcomatoid YSTpt did not express FOXA2 [0: 14/14 (100%)] and showed focal expression of GATA3 [0: 12/14 (85.7%), 1 + : 2/14 (14.3%)], thus suggesting that these markers are not useful in diagnosing this tumor. Furthermore, we proposed a potential mechanism of sarcomatoid transformation in the post-chemotherapy setting of GCTT, mediated by the downregulation of FOXA2 and GATA3.

Indexed as

Biomarkers, TumorDown-RegulationEndodermal Sinus TumorGATA3 Transcription FactorHepatocyte Nuclear Factor 3-betaPhenotypeTesticular NeoplasmsAdolescentAdultCell Transformation, NeoplasticGene Expression Regulation, NeoplasticGlypicansHumansImmunohistochemistryMaleNeoplasms, Germ Cell and EmbryonalBiomarkers, TumorFOXA2 protein, humanGATA3 protein, humanGATA3 Transcription FactorGlypicansHepatocyte Nuclear Factor 3-betaFOXA2GATA3Sarcomatoid yolk sac tumor postpubertal-typeSomatic-type malignancyYolk sac tumor postpubertal-type

Identifiers

PMID38141134
OpenAlexW4390144324

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.