ArticleWorld journal of pediatrics : WJP2024
Accurate prediction of biliary atresia with an integrated model using MMP-7 levels and bile acids.
Article in World journal of pediatrics : WJP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- The diagnostic accuracy of MMP-7 for the diagnosis for biliary atresia- a systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Serum matrix metalloproteinase-7 (MMP-7) as a Biomarker for differentiating biliary atresia from neonatal hepatitis: evidence synthesis through systematic review and meta-analysis.Pediatric surgery international · 2025Pooled it
- Comparison for the diagnostic performance of early diagnostic methods for biliary atresia: a systematic review and network meta-analysis.Pediatric surgery international · 2024Pooled it
- Diagnostic and management guidelines for biliary atresia in 2025.Hepatobiliary surgery and nutrition · 2026Review
- Non-Invasive Biomarkers for Assessing Liver Fibrosis in Biliary Atresia: A Literature Review.International journal of molecular sciences · 2026Review
- Diagnostic value of routine biochemical markers for biliary atresia in neonates with cholestasis: a retrospective study.Translational pediatrics · 2026Article
- A comprehensive diagnostic model based on serum MMP-7: a convenient and efficient early diagnostic method for biliary atresia.BMC pediatrics · 2026Article
- Development and external validation of a mitophagy-related diagnostic model for biliary atresia based on cellular infiltration patterns.Translational pediatrics · 2026Article
- Matrix Metalloproteinase 7 Mediates Epithelial-Mesenchymal Transition to Promote Liver Fibrosis Through E-cadherin/β-catenin Pathway in Biliary Atresia.International journal of molecular sciences · 2026Article
- Metabolic biomarkers for predicting onset and severity of CAR-T therapy-induced cytokine release syndrome in multiple myeloma.Frontiers of medicine · 2025Article
- Development and validation of a screening model for early diagnosis of biliary atresia in neonates with cholestasis.Pediatric surgery international · 2025Article
- Application of machine learning in constructing a diagnostic model for neonatal biliary atresia.Pediatric investigation · 2025Article
- A Scoring System Based on Diffusion Tensor Imaging and Blood Biochemistry Tests for Diagnosing Biliary Atresia in Infants.Children (Basel, Switzerland) · 2025Article
- Is performing the Kasai portoenterostomy in the neonatal period associated with a better prognosis? A single-center, retrospective cohort study from China.BMC pediatrics · 2025Article
- Unravelling interplay of serum MMP-7 and TGF- β in diabetic nephropathy - A study from a tertiary centre in eastern India.Journal of family medicine and primary care · 2025Article
- Progression characteristics of biliary atresia during the waiting period for liver transplantation: a single-center observational study.Frontiers in medicine · 2025Article
- Development of a diagnostic model for biliary atresia based on MMP7 and serological tests using machine learning.Pediatric surgery international · 2024Article
- Serum matrix metalloproteinase-7 for discriminating biliary atresia: a diagnostic accuracy and validation study.Journal of translational medicine · 2024Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBiliary atresia (BA) is a rare fatal liver disease in children, and the aim of this study was to develop a method to diagnose BA early.
methodsWe determined serum levels of matrix metalloproteinase-7 (MMP-7), the results of 13 liver tests, and the levels of 20 bile acids, and integrated computational models were constructed to diagnose BA.
resultsOur findings demonstrated that MMP-7 expression levels, as well as the results of four liver tests and levels of ten bile acids, were significantly different between 86 BA and 59 non-BA patients (P < 0.05). The computational prediction model revealed that MMP-7 levels alone had a higher predictive accuracy [area under the receiver operating characteristic curve (AUC) = 0.966, 95% confidence interval (CI): 0.942, 0.989] than liver test results and bile acid levels. The AUC was 0.890 (95% CI 0.837, 0.943) for liver test results and 0.825 (95% CI 0.758, 0.892) for bile acid levels. Furthermore, bile levels had a higher contribution to enhancing the predictive accuracy of MMP-7 levels (AUC = 0.976, 95% CI 0.953, 1.000) than liver test results. The AUC was 0.983 (95% CI 0.962, 1.000) for MMP-7 levels combined with liver test results and bile acid levels. In addition, we found that MMP-7 levels were highly correlated with gamma-glutamyl transferase levels and the liver fibrosis score.
conclusionThe innovative integrated models based on a large number of indicators provide a noninvasive and cost-effective approach for accurately diagnosing BA in children. Video Abstract (MP4 142103 KB).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.