Evidence map›Paper›PMID 38140908›Full record

ReviewCytoskeleton (Hoboken, N.J.)2024

Intraflagellar transport: A critical player in photoreceptor development and the pathogenesis of retinal degenerative diseases.

Mohona Gupta, Gregory J Pazour

Open access · bronzeAbstract readReview
In one paragraph

Review in Cytoskeleton (Hoboken, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Kinesins inOpen biology · 2025
    Review
  2. Review
  3. Review
  4. Article
  5. Intraflagellar Transport (IFT) and Sperm Formation.Advances in experimental medicine and biology · 2025
    Review
  6. Contribution of intraflagellar transport to compartmentalization and maintenance of the photoreceptor cell.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Cilia Structure and Function in Human Disease.Current opinion in endocrine and metabolic research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mohona GuptaProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID https://orcid.org/0000-0003-0659-2919
Gregory J PazourProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID https://orcid.org/0000-0002-6285-8796
University of Massachusetts Chan Medical School · US

Funding

Intraflagellar Transport Proteins in MiceR01GM060992 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Gregory J Pazour · 2001 to 2026
$10.3M
Function of Ciliary Disease Protein Retinitis Pigmentosa GTPase Regulator (RPGR)R01EY022372 · NEI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI PAZOUR, GREGORY J · 2012 to 2020
$3.7M
NEI NIH HHS R01 EY022372NIGMS NIH HHS R01 GM060992NIH HHS
6 · The paper itself

Abstract

In vertebrate vision, photons are detected by highly specialized sensory cilia called outer segments. Photoreceptor outer segments form by remodeling the membrane of a primary cilium into a stack of flattened disks. Intraflagellar transport (IFT) is critical to the formation of most types of eukaryotic cilia including the outer segments. This review covers the state of knowledge of the role of IFT in the formation and maintenance of outer segments and the human diseases that result from mutations in genes encoding the IFT complex and associated motors.

Indexed as

CiliaRetinal DegenerationAnimalsBiological TransportFlagellaHumansPhotoreceptor Cells, Vertebrateciliaciliopathyflagellaintraflagellar transportouter segmentphotoreceptorretinal degeneration

Identifiers

PMID38140908
PMCPMC11193844
OpenAlexW4390143280

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.