Changes in the Murine Microbiome and Bacterial Extracellular Vesicle Production in Response to Antibiotic Treatment and Norovirus Infection.

Chanel A Mosby, Kendall J Long, Matthew B Phillips, Julia Bartel, Melissa K Jones

Open access · goldAbstract read

In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 76% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chanel A MosbyMicrobiology and Cell Science Department, IFAS, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0002-5848-5229

Kendall J LongMicrobiology and Cell Science Department, IFAS, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0003-3159-246X

Matthew B PhillipsMolecular Genetics and Microbiology Department, College of Medicine, University of Florida, Gainesville, FL 32611, USA.

Julia BartelMicrobiology and Cell Science Department, IFAS, University of Florida, Gainesville, FL 32611, USA.

Melissa K JonesMicrobiology and Cell Science Department, IFAS, University of Florida, Gainesville, FL 32611, USA.

University of Florida · US

Funding

National Institute of Food and Agriculture Hatch project 7004422University of Florida Microbiology and Cell Science Department

6 · The paper itself

Abstract

Norovirus infection is influenced by the presence of commensal bacteria, and both human and murine norovirus (MNV) bind to these bacteria. These virus-bacterial interactions, as well as MNV infection, promote the increased production of bacterial extracellular vesicles (bEVs). However, no correlation has been made between specific bacterial groups, their vesicles, and their impact on norovirus infection. The current study evaluated the impact of select bacterial compositions of murine microbiomes using antibiotic (ABX) cocktails on MNV infection and bEV production. The goal of this research was to determine if increases in bEVs following MNV infection in mice were associated with changes in specific bacterial populations. Bacterial taxa were found to be differentially abundant in both ABX-treated and untreated mice, with the greatest change in bacterial taxa seen in mice treated with a broad-spectrum ABX cocktail. Specifically,

Indexed as

Caliciviridae InfectionsMicrobiotaAnimalsAnti-Bacterial AgentsHumansMiceAnti-Bacterial Agents16S sequencingbacterial extracellular vesiclesbEVLachnospiraeaemicrobiome compositionMNV infectionmurine norovirusOMVouter membrane vesicle

Identifiers

PMID38140684

DOI10.3390/v15122443

PMCPMC10747002

OpenAlexW4389894108

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.