Evidence map›Paper›PMID 38140650›Full record

ArticleViruses2023

Elevated Plasma Protein Carbonyl Concentration Is Associated with More Abnormal White Matter in People with HIV.

Patricia K Riggs, Albert M Anderson, Bin Tang, Leah H Rubin, Susan Morgello, Christina M Marra, Benjamin B Gelman, David B Clifford, Donald Franklin, Robert K Heaton and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Patricia K RiggsDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, CA 92093, USA.
Albert M AndersonDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Bin TangDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.
Leah H RubinDepartments of Neurology, Psychiatry and Behavioral Sciences, and Epidemiology, The Johns Hopkins University, Baltimore, MD 21205, USA.
Susan MorgelloDepartments of Neurology, Neuroscience, and Pathology, Mt Sinai School of Medicine, New York, NY 10029, USA.
Christina M MarraDepartment of Neurology, University of Washington, Seattle, WA 98195, USA.
Benjamin B GelmanDepartments of Pathology, and Neuroscience & Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
David B CliffordDepartment of Neurology, Washington University in St Louis, St Louis, MO 63110, USA.
Donald FranklinDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.
Robert K HeatonDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.
Ronald J EllisDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.
Christine Fennema-NotestineDepartment of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.
Scott L LetendreDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, CA 92093, USA.
University of California, San Diego · USEmory University · USIcahn School of Medicine at Mount Sinai · USJohns Hopkins University · USThe University of Texas Medical Branch at Galveston · USUniversity of Washington · USWashington University in St. Louis · US

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jessica Lynette Montoya · 2001 to 2026
$50.4M
CHARTER Plus: A resource for cutting-edge research on neurological function and mental health in people with HIV and substance use disorders across the lifespanR24MH129166 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RONALD J. ELLIS, Scott L Letendre · 2022 to 2026
$9.9M
HOPE Training GrantT32AI007384 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sara Gianella Weibel, Scott L Letendre · 1990 to 2026
$9.7M
Age related determinants of HAND: A 12 year follow-up of CHARTER participantsR01MH107345 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEATON, ROBERT KERNACHAN, LETENDRE, SCOTT L · 2015 to 2021
$7.9M
NIAID NIH HHS T32 AI007384NIMH NIH HHS P30 MH062512NIMH NIH HHS R01 MH107345NIMH NIH HHS R24 MH129166
6 · The paper itself

Abstract

Structural brain abnormalities, including those in white matter (WM), remain common in people with HIV (PWH). Their pathogenesis is uncertain and may reflect multiple etiologies. Oxidative stress is associated with inflammation, HIV, and its comorbidities. The post-translational carbonylation of proteins results from oxidative stress, and circulating protein carbonyls may reflect this. In this cross-sectional analysis, we evaluated the associations between protein carbonyls and a panel of soluble biomarkers of neuronal injury and inflammation in plasma (N = 45) and cerebrospinal fluid (CSF,

Indexed as

HIV InfectionsWhite MatterBlood ProteinsCross-Sectional StudiesFemaleHumansInflammationMaleMiddle AgedProtein CarbonylationBlood ProteinsbrainHIVmagnetic resonance imagingoxidative stresswhite matter

Identifiers

PMID38140650
PMCPMC10747698
OpenAlexW4389618321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.