Evidence map›Paper›PMID 38140348›Full record

ArticleNutrients2023

Optimized Sugar-Free Citrus Lemon Juice Fermentation Efficiency and the Lipid-Lowering Effects of the Fermented Juice.

Chang-Lu Hsu, Wen Pei, Tzu-Chun Chen, Ming-Chieh Hsu, Pei-Chun Chen, Heng-Miao Kuo, Jeng-Fung Hung, Yi-Jinn Lillian Chen

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chang-Lu HsuCollege of Management, Chung Hua University, Hsinchu 30012, Taiwan.
Wen PeiCollege of Management, Chung Hua University, Hsinchu 30012, Taiwan.
Tzu-Chun ChenGraduate Institute of Science Education & Environmental Education, National Kaohsiung Normal University, Kaohsiung 82444, Taiwan.
Ming-Chieh HsuGraduate Institute of Science Education & Environmental Education, National Kaohsiung Normal University, Kaohsiung 82444, Taiwan.
Pei-Chun ChenGraduate Institute of Science Education & Environmental Education, National Kaohsiung Normal University, Kaohsiung 82444, Taiwan.
Heng-Miao KuoInstitute of Phytochemicals Jianmao Biotech Co., Ltd., Kaohsiung 80672, Taiwan.
Jeng-Fung HungGraduate Institute of Science Education & Environmental Education, National Kaohsiung Normal University, Kaohsiung 82444, Taiwan.
Yi-Jinn Lillian ChenInstitute of Phytochemicals Jianmao Biotech Co., Ltd., Kaohsiung 80672, Taiwan.
National Kaohsiung Normal University · TWChung Hua University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging and obesity make humans more prone to cardiovascular and metabolic syndrome diseases, leading to several serious health conditions, including hyperlipidemia, high blood pressure, and sleep disturbance. This study aimed to explore the hypolipidemic effect of fermented citrus lemon juice using a hyperlipidemic hamster model. The sugar-free lemon juice's fermentation was optimized, and the characteristics of fresh and fermented lemon juice (FLJ) were evaluated and compared, which contained polyphenols and superoxide dismutase-like activity. Results showed that the absorption and utilization efficiency of FLJ was higher compared with the unfermented lemon juice. This study's prefermentation efficiency evaluation found that 21-30 days of bacterial DMS32004 and DMS32005 fermentation of fresh lemon juice provided the best fermentation benefits, and 21-day FLJ was applied as a remedy after the efficiency compassion. After six weeks of feeding, the total cholesterol (TC) and triglyceride (TG) values in the blood and liver of the FLJ treatment groups were decreased compared with the high-fat diet (HFD) group. In addition, the blood low-density lipoprotein cholesterol (LDL-C) levels were significantly reduced in the FLJ treatment groups compared with the HFD group. In contrast, the blood high-density lipoprotein (HDL-C) to LDL-C ratio increased considerably in the FLJ treatment groups, and the total to HDL ratio was significantly lower than in the HFD group. Compared with the HFD group, the TC content in the FLJ treatment groups' feces increased significantly. This study demonstrated that the sugar-free fermentation method and fermentation cycle management provided FLJ with the potential to regulate blood lipids. Further research and verification will be carried out to isolate specific substances from the FLJ and identify their mechanisms of action.

Indexed as

CitrusHyperlipidemiasAnimalsCholesterol, LDLCricetinaeDiet, High-FatFermentationHumansLipidsTriglyceridesCholesterol, LDLLipidsTriglyceridesefficiencyfermentation evaluationfermented lemon juicehyperlipidemialipid-lowering

Identifiers

PMID38140348
PMCPMC10745609
OpenAlexW4389678746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.