Evidence map›Paper›PMID 38140291›Full record

ArticleNutrients2023

High-Dose Vitamin D Supplementation Significantly Affects the Placental Transcriptome.

Anna Louise Vestergaard, Matilde K Andersen, Rasmus V Olesen, Pinar Bor, Agnete Larsen

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Associations Between Prenatal Vitamin D and Placental Gene Expression.bioRxiv : the preprint server for biology · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anna Louise VestergaardDepartment of Obstetrics and Gynecology, Randers Regional Hospital, 8930 Randers, Denmark.ORCID 0000-0002-8101-8573
Matilde K AndersenDepartment of Obstetrics and Gynecology, Randers Regional Hospital, 8930 Randers, Denmark.ORCID 0009-0007-2950-8288
Rasmus V OlesenDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Pinar BorDepartment of Obstetrics and Gynecology, Randers Regional Hospital, 8930 Randers, Denmark.
Agnete LarsenDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Aarhus University · DK

Funding

Aarhus University xAase og Ejnar Danielsens Fond xA.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond xAugustinus Foundation xAxel Muusfeldts Fond xDanish Medical Association xThe Toyota Foundation x
6 · The paper itself

Abstract

Vitamin D deficiency is a highly prevalent obstetrical concern associated with an increased risk of complications like pre-eclampsia, gestational diabetes, and growth retardation. Vitamin D status in pregnancy is also linked to long-term offspring health, e.g., the risk of obesity, metabolic disease, and neurodevelopmental problems. Despite the suspected role of vitamin D in placental diseases and fetal development, there is limited knowledge on the effect of vitamin D on placental function. Thus, we performed next-generation RNA sequencing, comparing the placental transcriptome from uncomplicated term pregnancies receiving the often-recommended dose of 10 µg vitamin D/day (

Indexed as

Pre-EclampsiaVitamin D DeficiencyDietary SupplementsFemaleHumansPlacentaPregnancyTranscriptomeVitamin DVitaminsVitamin DVitaminsimmune functionNGSplacentapregnancyvitamin D

Identifiers

PMID38140291
PMCPMC10745524
OpenAlexW4389486688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.