Evidence map›Paper›PMID 38140200›Full record

ArticleVaccines2023

BNT162b2 Booster Dose Elicits a Robust Antibody Response in Subjects with Abdominal Obesity and Previous SARS-CoV-2 Infection.

Alexis Elias Malavazos, Carola Dubini, Valentina Milani, Sara Boveri, Chiara Meregalli, Caterina Bertolini, Carola Buscemi, Rosanna Cardani, Laura Valentina Renna, Manuel Bruno Trevisan and 10 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 2 countries.

Alexis Elias MalavazosEndocrinology Unit, Clinical Nutrition and Cardiometabolic Prevention Service, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.ORCID 0000-0002-0852-9625
Carola DubiniEndocrinology Unit, Clinical Nutrition and Cardiometabolic Prevention Service, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.ORCID 0000-0003-1743-6516
Valentina MilaniLaboratory of Biostatistics and Data Management, Scientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.
Sara BoveriLaboratory of Biostatistics and Data Management, Scientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.ORCID 0000-0003-3144-9364
Chiara MeregalliEndocrinology Unit, Clinical Nutrition and Cardiometabolic Prevention Service, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.
Caterina BertoliniVaccination Unit, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
Carola BuscemiUnit of Internal Medicine, V. Cervello Hospital, 90146 Palermo, Italy.ORCID 0000-0002-4245-8373
Rosanna CardaniBiobank BioCor, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.ORCID 0000-0001-8858-4327
Laura Valentina RennaBiobank BioCor, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.ORCID 0000-0003-1316-7478
Manuel Bruno TrevisanEndocrinology Unit, Clinical Nutrition and Cardiometabolic Prevention Service, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.
Valentina ScravaglieriEndocrinology Unit, Clinical Nutrition and Cardiometabolic Prevention Service, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.
Maria Teresa CupponeScientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.
Lorenzo MenicantiScientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.
Elena CostaService of Laboratory Medicine, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.
Federico AmbrogiLaboratory of Biostatistics and Data Management, Scientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy.ORCID 0000-0001-9358-011X
Chiara RuoccoCentre for Study and Research on Obesity, Department of Medical Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy.
Michele CarrubaCentre for Study and Research on Obesity, Department of Medical Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy.
Gianluca IacobellisDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami, Miami, FL 33136, USA.
Enzo NisoliCentre for Study and Research on Obesity, Department of Medical Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy.ORCID 0000-0002-6670-1630
Massimiliano Marco Corsi RomanelliDepartment of Biomedical Sciences for Health, University of Milan, 00133 Milan, Italy.ORCID 0000-0001-7928-7697
IRCCS Policlinico San Donato · ITUniversity of Milan · ITASST Fatebenefratelli Sacco · ITOspedale Vincenzo Cervello · ITUniversity of Miami · US

Funding

GSD Foundation NARicerca Corrente NA
6 · The paper itself

Abstract

Little is known about the long-term durability of the induced immune response in subjects with obesity, particularly in those with an abdominal distribution of adipose tissue. We evaluated SARS-CoV-2-specific antibody responses after BNT162b2 vaccine booster dose, comparing individuals with and without abdominal obesity (AO), discerning between individuals previously infected or not. IgG-TrimericS were measured in 511 subjects at baseline, on the 21st day after vaccine dose 1, and at 1, 3, 6, and 9 months from dose 2, and at 1 and 3 months following the booster dose. To detect SARS-CoV-2 infection, nucleocapsid antibodies were measured at baseline and at the end of the study. Multivariable linear regression evaluated the three-month difference in the absolute variation in IgG-TrimericS levels from booster dose, showing AO and SARS-CoV-2 infection status interactions (

Indexed as

abdominal obesityantibody responseBMIBNT162b2 mRNA vaccinebooster doseCOVID-19IgG-TrimericSobesity

Identifiers

PMID38140200
PMCPMC10747120
OpenAlexW4389225578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.