Evidence map›Paper›PMID 38140177›Full record

ArticleVaccines2023

Testing a Recombinant Form of Tetanus Toxoid as a Carrier Protein for Glycoconjugate Vaccines.

Davide Oldrini, Roberta Di Benedetto, Martina Carducci, Daniele De Simone, Luisa Massai, Renzo Alfini, Barbara Galli, Brunella Brunelli, Amanda Przedpelski, Joseph T Barbieri and 5 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Adjuvanted Modified Bacterial Antigens for Single-Dose Vaccines.International journal of molecular sciences · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Davide OldriniGSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.ORCID 0000-0001-7827-6582
Roberta Di BenedettoGSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.
Martina CarducciGSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.ORCID 0000-0001-6633-567X
Daniele De SimoneGSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.
Luisa MassaiGSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.
Renzo AlfiniGSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.ORCID 0000-0001-7103-0723
Barbara GalliGSK, via Fiorentina 1, 53100 Siena, Italy.
Brunella BrunelliGSK, via Fiorentina 1, 53100 Siena, Italy.
Amanda PrzedpelskiDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Joseph T BarbieriDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Omar RossiGSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.ORCID 0000-0002-0170-1285
Carlo GiannelliGSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.ORCID 0000-0002-6112-6841
Rino RappuoliFondazione Biotecnopolo, via Fiorentina 1, 53100 Siena, Italy.
Francesco BertiGSK, via Fiorentina 1, 53100 Siena, Italy.
Francesca MicoliGSK Vaccines Institute for Global Health (GVGH), via Fiorentina 1, 53100 Siena, Italy.
Toscana Life Sciences · ITMedical College of Wisconsin · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycoconjugate vaccines play a major role in the prevention of infectious diseases worldwide, with significant impact on global health, enabling the polysaccharides to induce immunogenicity in infants and immunological memory. Tetanus toxoid (TT), a chemically detoxified bacterial toxin, is among the few carrier proteins used in licensed glycoconjugate vaccines. The recombinant full-length 8MTT was engineered in

Indexed as

carrier proteinglycoconjugatetetanus toxoid

Identifiers

PMID38140177
PMCPMC10747096
OpenAlexW4389114754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.