Evidence map›Paper›PMID 38140133›Full record

ArticlePharmaceutics2023

A Novel Handrub Tablet Loaded with Pre- and Post-Biotic Solid Lipid Nanoparticles Combining Virucidal Activity and Maintenance of the Skin Barrier and Microbiome.

Ana Carolina Henriques Ribeiro Machado, Laís Júlio Marinheiro, Heather Ann Elizabeth Benson, Jeffrey Ernest Grice, Tereza da Silva Martins, Alexandra Lan, Patricia Santos Lopes, Newton Andreo-Filho, Vania Rodrigues Leite-Silva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Postbiotics: an insightful review of the latest category in functional biotics.World journal of microbiology & biotechnology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ana Carolina Henriques Ribeiro MachadoPrograma de Pós-Graduação em Medicina Translacional, Universidade Federal de São Paulo, Rua Pedro de Toledo, 720, Sao Paulo 04039-002, SP, Brazil.
Laís Júlio MarinheiroDepartamento de Ciências Farmacêuticas, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Rua São Nicolau, 210, Diadema 09913-030, SP, Brazil.
Heather Ann Elizabeth BensonCurtin Medical School, Curtin University, Perth, WA 6845, Australia.ORCID 0000-0002-1818-5627
Jeffrey Ernest GriceFrazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.
Tereza da Silva MartinsLaboratório de Materiais Híbridos, Departamento de Química, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Rua São Nicolau, 210, 2° Andar, Diadema 09913-030, SP, Brazil.
Alexandra LanShanghai Pechoin Daily Chemical Corporation, Shanghai 200060, China.
Patricia Santos LopesDepartamento de Ciências Farmacêuticas, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Rua São Nicolau, 210, Diadema 09913-030, SP, Brazil.ORCID 0000-0003-1353-9825
Newton Andreo-FilhoDepartamento de Ciências Farmacêuticas, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Rua São Nicolau, 210, Diadema 09913-030, SP, Brazil.ORCID 0000-0002-9431-3088
Vania Rodrigues Leite-SilvaPrograma de Pós-Graduação em Medicina Translacional, Universidade Federal de São Paulo, Rua Pedro de Toledo, 720, Sao Paulo 04039-002, SP, Brazil.
The University of Queensland · AUInstituto de Ciências Farmacêuticas · BRUniversidade Federal de São Paulo · BRCurtin University · AU

Funding

Embrapii - Empresa Brasileira de Pesquisa e Inovação Industrial UNIFESP Process Nº 23089.125507 / 2020-08, Project Code PFSP-2101.0005
6 · The paper itself

Abstract

objectiveThis study aimed to develop a holobiont tablet with rapid dispersibility to provide regulation of the microbiota, virucidal activity, and skin barrier protection.

methodsA 2

resultsA handrub tablet with rapid dispersibility was developed for topical use and rinse off. After being defined as safe, the virucidal activity was found to be equal to or greater than that of 70% alcohol, with a reduction in interleukins and maintenance or improvement of skin barrier gene markers, in addition to the reestablishment of the skin microbiota after use.

conclusionsThe holobiont tablets were able to improve the genetic markers related to the skin barrier and also its microbiota, thereby being more favorable for use as a hand sanitizer than 70% alcohol.

Indexed as

handrub tabletmicrobiomeskin barriersolid lipid nanoparticlesvirucide

Identifiers

PMID38140133
PMCPMC10747770
OpenAlexW4389893953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.