Evidence map›Paper›PMID 38140040›Full record

ArticlePharmaceutics2023

Zeyar Mohammed Ali, Marinda Meertens, Beatriz Fernández, Pere Fontova, Anna Vidal-Alabró, Raul Rigo-Bonnin, Edoardo Melilli, Josep M Cruzado, Josep M Grinyó, Helena Colom and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. State of Art of Dose Individualization to Support tacrolimus drug monitoring: What's Next?Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Zeyar Mohammed AliNephrology Department, Hospital Universitari de Bellvitge-IDIBELL, 08908 Barcelona, Spain.
Marinda MeertensNephrology Department, Hospital Universitari de Bellvitge-IDIBELL, 08908 Barcelona, Spain.
Beatriz FernándezNephrology Department, Hospital Universitari de Bellvitge-IDIBELL, 08908 Barcelona, Spain.
Pere FontovaNephrology Department, Hospital Universitari de Bellvitge-IDIBELL, 08908 Barcelona, Spain.ORCID 0000-0002-1352-3084
Anna Vidal-AlabróNephrology Department, Hospital Universitari de Bellvitge-IDIBELL, 08908 Barcelona, Spain.
Raul Rigo-BonninBiochemistry Department, Hospital Universitari de Bellvitge-IDIBELL, 08908 Barcelona, Spain.ORCID 0000-0001-5511-074X
Edoardo MelilliNephrology Department, Hospital Universitari de Bellvitge-IDIBELL, 08908 Barcelona, Spain.ORCID 0000-0001-6965-3745
Josep M CruzadoNephrology Department, Hospital Universitari de Bellvitge-IDIBELL, 08908 Barcelona, Spain.
Josep M GrinyóDepartment of Clinical Sciences, Medicine Unit, University of Barcelona, 08007 Barcelona, Spain.
Helena ColomBiopharmaceutics and Pharmacokinetics Unit, Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, School of Pharmacy, University of Barcelona, 08007 Barcelona, Spain.
Nuria LloberasNephrology Department, Hospital Universitari de Bellvitge-IDIBELL, 08908 Barcelona, Spain.
Bellvitge University Hospital · ESUniversitat de Barcelona · ES

Funding

Instituto de Salud Carlos III PI18/01740Instituto de Salud Carlos III PI21/00559RICORS RD21/00050021
6 · The paper itself

Abstract

The aim of the study is to develop a population pharmacokinetic (PopPK) model and to investigate the influence of CYP3A5/CYP3A4 and ABCB1 single nucleotide polymorphisms (SNPs) on the Tacrolimus PK parameters after LCP-Tac formulation in stable adult renal transplant patients. The model was developed, using NONMEM v7.5, from full PK profiles from a clinical study (n = 30) and trough concentrations (C

Indexed as

ABCB1CYP3A4CYP3A5immunosuppressionLCP-Tacpopulation pharmacokineticsrenal transplantationstable adult patientsTacrolimus

Identifiers

PMID38140040
PMCPMC10747255
OpenAlexW4389144807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.